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Cas Database

423-46-1

423-46-1

Identification

  • Product Name:1H,1H-Perfluorohexan-1-ol

  • CAS Number: 423-46-1

  • EINECS:

  • Molecular Weight:300.072

  • Molecular Formula: C6H3F11O

  • HS Code:29055900

  • Mol File:423-46-1.mol

Synonyms:1,1-Dihydroperfluorohexanol;1H,1H-Perfluoro-1-hexanol;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TCI Chemical
  • Product Description:1H,1H-Undecafluoro-1-hexanol >96.0%(GC)
  • Packaging:5g
  • Price:$ 94
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:25 g
  • Price:$ 145
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:5 g
  • Price:$ 55
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:1 g
  • Price:$ 25
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:100 g
  • Price:$ 395
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:1H,1H-Perfluorohexan-1-ol
  • Packaging:10 g
  • Price:$ 650
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:5g
  • Price:$ 89
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:1H,1H-Perfluorohexan-1-ol 98%
  • Packaging:25g
  • Price:$ 365
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1H,1H-PERFLUOROHEXAN-1-OL 95.00%
  • Packaging:25G
  • Price:$ 1164.66
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1H,1H-PERFLUOROHEXAN-1-OL 95.00%
  • Packaging:5G
  • Price:$ 797.32
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

A process for the preparation of the fluoro method

-

, (2017/06/29)

The invention relates to a method of preparing fluoroalcohol of which the structure formula is F3C(CF2)nCH2OH, wherein n is an integer of 2-8. The method includes following steps: (I) mixing fluorocarboxylic acid and isopropyl alcohol and performing a temperature-increasing reflux reaction; (II) when the reaction is finished, distilling the reaction liquid to remove generated water and isopropyl alcohol, and cooling the rest reaction liquid to room temperature; (III) pouring the reaction liquid into distillated water, regulating the pH value to 6.5-7 by an alkali liquid, allowing the reaction liquid to stand to layer the reaction liquid to obtain an organic layer; (IV) removing water from the organic layer to obtain fluorocarboxylic isopropyl ester; (V) adding the fluorocarboxylic isopropyl ester and a solvent into a high-pressure reaction kettle with addition of a hydrogenation catalyst and a co-catalyst, sealing the reaction kettle, increasing the temperature and filling hydrogen to a high pressure for performing a reaction for 20-60 h; (VI) when the reaction is finished, cooling the reaction kettle to room temperature, discharging hydrogen to obtain a reaction mixed liquid; (VII) performing rectification to the reaction mixed liquid to separate the solvent, cooling the rest liquid and pouring the rest liquid into distillated water and regulating the pH value to 6.5-7 by an acid liquid; and (VIII) allowing the mixed liquid to stand to layer the mixed liquid to obtain an organic layer, removing water from the organic layer and distilling the organic layer to obtain the corresponding fluoroalcohol.

Homogeneous catalytic hydrogenation of perfluoro methyl esters

Lazzari, Dario,Cassani, Maria Cristina,Bertola, Maurizio,Moreno, Francisco Casado,Torrente, Damiano

, p. 15582 - 15584 (2013/09/12)

The first example of perfluoroalkyl methyl ester RfC(O)OMe (Rf = C3F7, C5F11) reduction by homogeneous catalytic hydrogenation with the ruthenium catalyst Ru-MACHO is herein reported. The hydrogenation process leads to the corresponding perfluorinated alcohols thus replacing sodium borohydride that has so far represented the state of art in perfluoro ester reduction.

Various synthetic approaches to fluoroalkyl p-nitrophenyl ethers

Preschera, Dietrich,Thiele, Thomas,Ruhmann, Ralf

, p. 145 - 148 (2007/10/03)

Homologous 1H,1H-perfluoroalkyl p-nitrophenyl ethers (alkyl = C2-C8) were synthesized using different methods. The results are discussed in context with contradictory comments of the literature. The fluoroalkoxylation of p-chloronitrobenzene occurs in only one step, but it is limited to small fluoroalkyl groups. The fluoroalkylation of p-nitrophenol via sulphonic acid esters is a better synthetic route. Differences in reactivity and yield between tosylates, mesylates and inflates are found and discussed. The preferred synthesis includes the use of trifluoromethane sulphonic acid esters.

Process route upstream and downstream products

Process route

isopropyl 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoate

isopropyl 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoate

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With RuCl2(DPPEA)(±DAIPEN); hydrogen; sodium methylate; In isopropyl alcohol; at 120 ℃; for 60h; under 750.075 - 30003 Torr; Autoclave;
93%
perfluorohexanoic acid methyl ester
424-18-0

perfluorohexanoic acid methyl ester

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With carbonylchlorohydrido[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen; sodium methylate; In methanol; at 60 ℃; for 23h; under 7500.75 Torr; Temperature; Autoclave;
86%
undecafluorohexanoic acid
307-24-4

undecafluorohexanoic acid

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With lithium aluminium tetrahydride;
Multi-step reaction with 2 steps
1: 3 h / Reflux
2: RuCl2(DPPEA)(±DAIPEN); sodium methylate; hydrogen / isopropyl alcohol / 60 h / 120 °C / 750.08 - 30003 Torr / Autoclave
With RuCl2(DPPEA)(±DAIPEN); hydrogen; sodium methylate; In isopropyl alcohol;
With lithium aluminium tetrahydride; diethyl ether;
perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
Undecafluorhexansaeure, LiAlH4;
isopropyl 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoate

isopropyl 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoate

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With RuCl2(DPPEA)(±DAIPEN); hydrogen; sodium methylate; In isopropyl alcohol; at 120 ℃; for 60h; under 750.075 - 30003 Torr; Autoclave;
93%
perfluorohexanoic acid methyl ester
424-18-0

perfluorohexanoic acid methyl ester

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With carbonylchlorohydrido[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen; sodium methylate; In methanol; at 60 ℃; for 23h; under 7500.75 Torr; Temperature; Autoclave;
86%
undecafluorohexanoic acid
307-24-4

undecafluorohexanoic acid

perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
With lithium aluminium tetrahydride;
Multi-step reaction with 2 steps
1: 3 h / Reflux
2: RuCl2(DPPEA)(±DAIPEN); sodium methylate; hydrogen / isopropyl alcohol / 60 h / 120 °C / 750.08 - 30003 Torr / Autoclave
With RuCl2(DPPEA)(±DAIPEN); hydrogen; sodium methylate; In isopropyl alcohol;
With lithium aluminium tetrahydride; diethyl ether;
perfluorohexanol
423-46-1

perfluorohexanol

Conditions
Conditions Yield
Undecafluorhexansaeure, LiAlH4;

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Career Henan Chemical Co
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  • Finetech Industry Limited
  • Business Type:Trading Company
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  • Antimex Chemical Limied
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  • Skyrun Industrial Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-576-84610586
  • Emails:sales@chinaskyrun.com
  • Main Products:18
  • Country:China (Mainland)
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