42553-65-1 Usage
Introduction
Crocin (crocin) is also known as a-crocin and crocetin. It is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars. It is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.It is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.
Efficacy and effect
The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain. It is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury.?The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure. Because the water solution of stigma croci is bright yellow with sweet smell, it is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products. In recent years, pharmacological researches indicate that stigma croci has good control effect for a variety of diseases, including cancer, coronary heart disease, atherosclerosis and hyperlipidemia.
Pharmacological effects
Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects. It is widely used in food, medicine, chemical industry and other industries. It is used in the treatment of patients with cardiovascular disease and fatty liver.with good medicinal value.
Description
Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.
Chemical Properties
Solid
Uses
Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
General Description
A highly unsaturared diterpene dicarboxylic acid ester found in saffron.
Biochem/physiol Actions
Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory. Related CNS effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.
Check Digit Verification of cas no
The CAS Registry Mumber 42553-65-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,5,5 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42553-65:
(7*4)+(6*2)+(5*5)+(4*5)+(3*3)+(2*6)+(1*5)=111
111 % 10 = 1
So 42553-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C46H68O23/c1-21(12-8-14-23(3)25(5)18-62-43-40(59)36(55)32(51)28(67-43)19-63-44-38(57)34(53)30(49)26(16-47)65-44)10-6-7-11-22(2)13-9-15-24(4)42(61)69-46-41(60)37(56)33(52)29(68-46)20-64-45-39(58)35(54)31(50)27(17-48)66-45/h6-15,26-41,43-60H,5,16-20H2,1-4H3/b7-6+,12-8+,13-9+,21-10-,22-11+,23-14-,24-15+/t26-,27-,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,43-,44-,45-,46+/m1/s1
42553-65-1Relevant articles and documents
SINGLET OXYGEN REACTIONS IN AQUEOUS SOLUTION. PHYSICAL AND CHEMICAL QUENCHING RATE CONSTANTS OF CROCIN AND RELATED CAROTENOIDS
Manitto, Paolo,Speranza, Giovanna,Monti, Diego,Gramatica, Paola
, p. 4221 - 4224 (2007/10/02)
Thermal decomposition of 3-(1,4-epidioxy-4-methyl-1,4-dihydro-1-naphthyl)propionic acid (2) has been used to measure both the physical and chemical quenching rate constants of 1O2 (kQ and kR, respectively) by water-soluble 8,8'-diapocarotenoids such as crocin (1a) and its derivatives (1b,c).The value of kQ was found to be slightly lower than the diffusion controlled rate constant in all the solvents examined, whereas kR showed strong dependence on the medium, going from ca. 108 in H2O to 106 M-1s-1 in DMF and DMSO.These findings suggest that both energy- and electron-transfer mechanisms are involved in the quenching of O2 (1Δg) by crocinoids.
