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Cas Database

4264-05-5

4264-05-5

Identification

  • Product Name:Isoxazole,3-(4-nitrophenyl)-

  • CAS Number: 4264-05-5

  • EINECS:

  • Molecular Weight:190.158

  • Molecular Formula: C9H6 N2 O3

  • HS Code:2934999090

  • Mol File:4264-05-5.mol

Synonyms:Isoxazole,3-(p-nitrophenyl)- (7CI,8CI); 3-(p-Nitrophenyl)isoxazole

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Safety information and MSDS view more

  • Pictogram(s):T

  • Hazard Codes:T

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
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  • Purchase
  • Manufacture/Brand:TCI Chemical
  • Product Description:3-(4-Nitrophenyl)isoxazole >96.0%(GC)
  • Packaging:1g
  • Price:$ 285
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:3-(4-Nitrophenyl)isoxazole >96.0%(GC)
  • Packaging:200mg
  • Price:$ 84
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:3-(4-Nitrophenyl)isoxazole,≥96%(GC) ≥96%(GC)
  • Packaging:250MG
  • Price:$ 126.03
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-(4-NITROPHENYL)ISOXAZOLE 95.00%
  • Packaging:10G
  • Price:$ 7882.88
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-(4-NITROPHENYL)ISOXAZOLE 95.00%
  • Packaging:5G
  • Price:$ 4244.63
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-(4-NITROPHENYL)ISOXAZOLE 95.00%
  • Packaging:1G
  • Price:$ 1030.84
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-(4-NITROPHENYL)ISOXAZOLE 95.00%
  • Packaging:0.1G
  • Price:$ 203
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:3-(4-Nitrophenyl)isoxazole
  • Packaging:200mg
  • Price:$ 159
  • Delivery:In stock
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Relevant articles and documentsAll total 10 Articles be found

Polymer-supported vinyl sulfone as an efficient reagent for the synthesis of 3-monosubstituted isoxazoles

Wu, Guo-Jian,Sheng, Shou-Ri,Li, Dan,Xu, Li-Fan,Huang, Zhen-Zhong

, p. 3034 - 3043 (2013/09/12)

Polystyrene-supported vinyl sulfone reagent has been developed and used for solid-phase organic synthesis of 3-monosubstituted isoxazoles by 1,3-dipolar cycloaddition reaction with nitrile oxides and subsequent cleavage from the polymer support through an

Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: Versatile synthons for isoxazoles, β-lactams, and γ-amino alcohols

Tang, Shibing,He, Jinmei,Sun, Yongquan,He, Liuer,She, Xuegong

scheme or table, p. 1961 - 1966 (2010/06/20)

"Chemical Equation Presented" An efficient and highly regioselective protocol was developed for the preparation of 5-hydroxy2-isoxazolines, which have been proved to be versatile synthons for isoxazles, β-hydroxy oximes, and γ-amino alcohols. β-Lactams, commonly embedded in the skeletons of bioactive natural products, were also synthesized in two steps from β-hydroxy oximes, providing a new strategy for the synthesis of this kind of compounds.

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

Tang, Shibing,He, Jinmei,Sun, Yongquan,He, Liuer,She, Xuegong

supporting information; experimental part, p. 3982 - 3985 (2009/12/03)

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

Traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines using polystyrene-supported vinyl selenide

Sheng, Shou-Ri,Xin, Qin,Liu, Xiao-Ling,Sun, Wu-Kang,Guo, Rui,Huang, Xian

, p. 2293 - 2296 (2008/02/02)

A novel facile procedure for the traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines in good yields and with excellent purities using polymer-supported vinyl selenide is described. The polymeric reagent can be

Substituent effects on 15N and 13C NMR chemical shifts of 3-phenylisoxazoles: A theoretical and spectroscopic study

Schofield, Mark H.,Sorel, Marie-Adele,Manalansan, Ryan J.,Richardson, David P.,Markgraf, J. Hodge

, p. 851 - 855 (2007/10/03)

The synthesis and assignment of 15N and 13C NMR signals of the isoxazole ring in a series of parasubstituted 3-phenyl derivatives are reported. DFT calculations of 15N and 13C chemical shifts are presented and c

Process route upstream and downstream products

Process route

dimethyl bicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylate
947-57-9

dimethyl bicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylate

p-nitrobenzonitrile oxide
2574-03-0

p-nitrobenzonitrile oxide

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

cyclopenta-1,3-diene
542-92-7,25568-84-7,7313-32-8

cyclopenta-1,3-diene

Cyclopenta-2,5-diene-1,2-dicarboxylic acid dimethyl ester
55949-76-3

Cyclopenta-2,5-diene-1,2-dicarboxylic acid dimethyl ester

3-(4-nitro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester
53890-65-6

3-(4-nitro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester

Conditions
Conditions Yield
In benzene; for 2h; Heating;
3.8 % Chromat.
96.2 % Chromat.
dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
1829-60-3

dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate

p-nitrobenzonitrile oxide
2574-03-0

p-nitrobenzonitrile oxide

furan
110-00-9

furan

dimethyl 3,4-furandicarboxylate
4282-33-1

dimethyl 3,4-furandicarboxylate

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

3-(4-nitro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester
53890-65-6

3-(4-nitro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester

Conditions
Conditions Yield
In benzene; Ambient temperature;
56.4 % Chromat.
43.6 % Chromat.
3-(4-nitrophenyl)-2-propenal
1734-79-8

3-(4-nitrophenyl)-2-propenal

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
3-(4-nitrophenyl)-2-propenal; With p-toluenesulfonylhydroxylamine; potassium carbonate; In methanol; water; at 20 ℃; for 1h;
With potassium carbonate; In methanol; water; at 60 ℃; for 1h; regioselective reaction;
88%
C<sub>15</sub>H<sub>11</sub>N<sub>2</sub>O<sub>5</sub>PolS

C15H11N2O5PolS

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 14h;
3-(4-nitrophenyl)-5-hydroxy-4,5-dihydroisoxazole
112853-64-2

3-(4-nitrophenyl)-5-hydroxy-4,5-dihydroisoxazole

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
With sodium methylate; In methanol; Heating;
95%
With dmap; triethylamine; p-toluenesulfonyl chloride; In acetonitrile; at 0 - 20 ℃; for 4h;
91%
bicyclo[2.2.1]hepta-2,5-diene
121-46-0

bicyclo[2.2.1]hepta-2,5-diene

4-nitrobenzaldehyde oxime
1129-37-9,174848-02-3,20707-69-1

4-nitrobenzaldehyde oxime

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
With sodium hypochlorite; In tetrahydrofuran; water;
3-(4-Nitro-phenyl)-5-phenylsulfanyl-4,5-dihydro-isoxazole

3-(4-Nitro-phenyl)-5-phenylsulfanyl-4,5-dihydro-isoxazole

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
With formic acid; dihydrogen peroxide; at 20 ℃; for 4.75h;
90%
polystyrene-supported vinyl selenide

polystyrene-supported vinyl selenide

4-nitrobenzaldehyde oxime
1129-37-9,174848-02-3,20707-69-1

4-nitrobenzaldehyde oxime

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
4-nitrobenzaldehyde oxime; With N-chloro-succinimide; In chloroform; at 20 ℃; for 0.333333h;
polystyrene-supported vinyl selenide; With triethylamine; In dichloromethane; at 20 ℃; for 12h;
With dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 0.5h; Further stages.;
vinyl phenyl selenide
35167-28-3

vinyl phenyl selenide

p-nitrobenzonitrile oxide
2574-03-0

p-nitrobenzonitrile oxide

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
vinyl phenyl selenide; p-nitrobenzonitrile oxide; With triethylamine; In chloroform; at 20 ℃; for 12h;
With dihydrogen peroxide; In chloroform; at 20 ℃; for 0.333333h;
p-nitrobenzonitrile oxide
2574-03-0

p-nitrobenzonitrile oxide

3-(p-nitrophenyl)isoxazole
4264-05-5

3-(p-nitrophenyl)isoxazole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 63 percent / tetrahydrofuran / 4 h / Ambient temperature
2: 90 percent / 36percent H2O2/HCOOH / 4.75 h / 20 °C
With formic acid; dihydrogen peroxide; In tetrahydrofuran;
Multi-step reaction with 2 steps
1: 85 percent / n-butyllithium / tetrahydrofuran
2: 95 percent / sodium methoxide / methanol / Heating
With n-butyllithium; sodium methylate; In tetrahydrofuran; methanol;

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  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
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