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Cas Database

4272-77-9

4272-77-9

Identification

  • Product Name:1-Naphthalenesulfonicacid, 5-(dimethylamino)-

  • CAS Number: 4272-77-9

  • EINECS:224-268-5

  • Molecular Weight:251.306

  • Molecular Formula: C12H13NO3S

  • HS Code:29214990

  • Mol File:4272-77-9.mol

Synonyms:1-(Dimethylamino)-5-naphthalenesulfonicacid;5-(Dimethylamino)-1-naphthalenesulfonic acid;Dansyl acid;N,N-Dimethyl-1-naphthylamine-5-sulfonicacid;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:Usbiological
  • Product Description:Dansyl Acid
  • Packaging:1g
  • Price:$ 319
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:Dansyl Acid
  • Packaging:25g
  • Price:$ 95
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Dansyl Acid >98.0%(HPLC)(T)
  • Packaging:25g
  • Price:$ 107
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:5-(dimethylamino)-1-naphthalenesulfonicacid
  • Packaging:10g
  • Price:$ 38
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-DIMETHYLAMINO-1-NAPHTHALENESULFONIC ACID MONOHYDRATE 95.00%
  • Packaging:10G
  • Price:$ 2055.9
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-DIMETHYLAMINO-1-NAPHTHALENESULFONIC ACID MONOHYDRATE 95.00%
  • Packaging:1G
  • Price:$ 704.55
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:Dansyl Acid
  • Packaging:5g
  • Price:$ 59
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:Dansyl Acid
  • Packaging:1g
  • Price:$ 20
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:Dansyl Acid
  • Packaging:25g
  • Price:$ 193
  • Delivery:In stock
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  • Manufacture/Brand:AHH
  • Product Description:Dansyl Acid 98%
  • Packaging:100g
  • Price:$ 476
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Relevant articles and documentsAll total 10 Articles be found

Dual signaling of thallium(III) ions via oxidative cleavage of a sulfonhydrazide linkage

Ahn, Sangdoo,Chang, Suk-Kyu,Choi, Myung Gil,Lee, Yu Jeong,Park, Tae Jung,Yoo, Jae Hoon

, (2020/03/17)

The thallium is widely used in various research and industrial applications but is very toxic. In this work, we developed a novel reaction-based dual signaling probe for the selective and sensitive determination of Tl3+ via the oxidative cleavage of a rhodamine–dansylhydrazide conjugate. The designed probe showed pronounced colorimetric and fluorescence signaling behavior toward Tl3+ with a detection limit of 1.3 × 10–7 M (0.027 ppm), as well as selectivity over other common metal ions, anions, and oxidants. The Tl3+ signaling process required less than 2 min and was not influenced by the solution pH within the range of 4.0–5.5; however, the signal diminished significantly above pH 6.0. To demonstrate the practical applicability of the designed probe, a simple and convenient colorimetric assay for the determination of Tl3+ in commercial reagents was established using an office scanner as a readily available signal capturing device.

Synthetic method of dansyl chloride for preparing fluorescent probe (by machine translation)

-

Paragraph 0029-0035, (2020/07/14)

The preparation method comprises the following steps: dissolving rhodamine sulfonic acid in an organic solvent to obtain an emulsion; sequentially dropwise adding thionyl chloride and phosphorus pentachloride into the suspension; controlling the temperature of the system to 40 - 45 °C; reacting 4 - 6h; adjusting pH to 5 - 6; and collecting the product to obtain the folic acid chloride. The invention further discloses a fluorescent probe prepared from the dansyl chloride. In the synthesis process of the target fluorescent compound, by adding the phosphorus pentachloride catalyst, the use amount of thionyl chloride is reduced, the reaction condition is mild, and the method can be carried out at a lower temperature. (by machine translation)

Preparation method of 6-deuterated dansyl chloride

-

Paragraph 0076-0078, (2020/12/14)

The invention belongs to the technical field of isotope derivatization reagent preparation, and particularly relates to a preparation method of 6-deuterated dansyl chloride. According to the preparation method, 6-deuterated dansyl chloride can be prepared from reaction raw materials including 5-amino-1-naphthalene sulfonic acid, sodium hydride, deuterated methyl iodide, phosphorus oxychloride andphosphorus pentachloride. The preparation method has the advantages of easily available raw materials, low toxicity, few intermediate products and high yield.

A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite

Lin, Ku-Kuei,Wu, Shou-Cheng,Hsu, Kuang-Mei,Hung, Chen-Hsiung,Liaw, Wen-Feng,Wang, Yun-Ming

supporting information, p. 4242 - 4245 (2013/09/12)

A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO-) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancem

A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore

Pauff, Steven M.,Miller, Stephen C.

supporting information, p. 711 - 716 (2013/02/25)

Sulfonated molecules exhibit high water solubility, a property that is valuable for many biological applications but often complicates their synthesis and purification. Here we report a sulfonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroacetic acid (TFA). The use of this protecting group improved the synthesis of a sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product without requiring chromatography.

Process route upstream and downstream products

Process route

1-aminonaphthalene-5-sulfonic acid
84-89-9

1-aminonaphthalene-5-sulfonic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With ammonia; sodium carbonate; In water; at 20 ℃; for 6h;
95.6%
With sodium hydrogencarbonate; In water; at 80 ℃; for 0.5h;
90%
With sodium hydrogencarbonate; at 80 ℃; for 0.5h; Yield given;
With sodium hydrogencarbonate; In water; at 0 - 80 ℃; for 1h; Inert atmosphere;
C<sub>40</sub>H<sub>43</sub>N<sub>5</sub>O<sub>4</sub>S

C40H43N5O4S

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With thallium(III) nitrate; In dimethyl sulfoxide; pH=4.76;
5-dimethylaminonaphthalene-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester
1415743-27-9

5-dimethylaminonaphthalene-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With trifluoroacetic acid; In water; at 20 ℃; for 2h;
99%
N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide
1254479-26-9

N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide

1,2,3-Benzotriazole
95-14-7,27556-51-0

1,2,3-Benzotriazole

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With Peroxynitrite anion; sodium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 0.00555556h; pH=7.4; Solvent; pH-value; Time;
5-(dimethylamino)-1-naphthalenesulfonyl fluoride
34523-28-9

5-(dimethylamino)-1-naphthalenesulfonyl fluoride

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 0.25h;
5-(dimethylamino)-1-naphthalenesulfinic acid
71288-39-6

5-(dimethylamino)-1-naphthalenesulfinic acid

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With dihydrogen peroxide; In water-d2;
N,N-dimethyl-1-naphthalenamine
86-56-6,112790-02-0,651316-60-8

N,N-dimethyl-1-naphthalenamine

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With sulfuric acid; at 130 ℃;
1-aminonaphthalene-5-sulfonic acid
84-89-9

1-aminonaphthalene-5-sulfonic acid

methyl iodide
74-88-4

methyl iodide

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
With methanol; sodium hydroxide; at 100 - 110 ℃; im Bombenrohr;
N,N-dimethyl-1-naphthalenamine
86-56-6,112790-02-0,651316-60-8

N,N-dimethyl-1-naphthalenamine

sulfuric acid
7664-93-9

sulfuric acid

dansyl acid
4272-77-9

dansyl acid

Conditions
Conditions Yield
at 130 ℃;
p-nitrobenzyl 5-dimethylaminonaphthalene-1-sulfonate
131317-48-1

p-nitrobenzyl 5-dimethylaminonaphthalene-1-sulfonate

1,2-bis(4-nitrophenyl)ethane
736-30-1

1,2-bis(4-nitrophenyl)ethane

dansyl acid
4272-77-9

dansyl acid

1-dimethylamino-5-(p-nitrobenzyl)naphthalene
141469-32-1

1-dimethylamino-5-(p-nitrobenzyl)naphthalene

Conditions
Conditions Yield
In acetonitrile; Mechanism; Quantum yield; Irradiation;

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