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42839-09-8

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42839-09-8 Usage

Uses

2-?Pyrimidinemethanol is a reactant used in the synthesis of avanafil, which is used to treat erectile dysfunction. Also used in the synthesis of

Check Digit Verification of cas no

The CAS Registry Mumber 42839-09-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,8,3 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 42839-09:
(7*4)+(6*2)+(5*8)+(4*3)+(3*9)+(2*0)+(1*9)=128
128 % 10 = 8
So 42839-09-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O/c8-4-5-6-2-1-3-7-5/h1-3,8H,4H2

42839-09-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Hydroxymethyl)pyrimidine

1.2 Other means of identification

Product number -
Other names 2-Pyrimidinemethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42839-09-8 SDS

42839-09-8Relevant articles and documents

Asymmetric zinc porphyrin derivatives bearing three pseudo-pyrimidine: Meso -position substituents and their photosensitization for H2evolution

Zeng, Peng,Zheng, Ya,Chen, Shengtao,Liu, Haoran,Li, Renjie,Peng, Tianyou

, p. 11237 - 11247 (2020/08/21)

Novel asymmetric zinc porphyrin derivatives (ZnPy-5 and ZnPy-6) with meso-positions bearing one benzoic acid and three pseudo-pyrimidines with two N atoms located at different positions were synthesized and utilized as sensitizers for Pt-loaded g-C3N4 (PCN). Compared to the analogue (ZnPy-1 bearing one benzoic acid and three phenyl meso-position substituents), ZnPy-5 and ZnPy-6 exhibit significantly enhanced photosensitization on PCN under visible light (λ ≥ 420 nm) illumination. In particular, ZnPy-5/PCN and ZnPy-6/PCN exhibit H2 evolution activities of 418 and 585 μmol h-1, corresponding to turnover numbers (TON) of 8845 and 12?381 h-1, respectively. Both of these values are much better that (316 μmol h-1) of ZnPy-1/PCN, which has a TON of 6687 h-1. In addition, ZnPy-5/PCN and ZnPy-6/PCN show apparent quantum yields of 32.6% and 33.1% at 420 nm monochromatic light, and these are much higher than that (10.6%) for ZnPy-1/PCN. Compared with ZnPy-5, the two N atoms of the pseudo-pyrimidines in ZnPy-6 are further away from the porphyrin macrocycle, which can more effectively combine with the sacrificial reagent and g-C3N4, thus promoting dye regeneration and the photoexcited charge transfer for delivering better photocatalytic performance. The present results demonstrate that the number and positions of the N atoms in the peripheral substituents of the porphyrin derivatives have a great influence on the photosensitization, and that the fine-tuning of molecular structures is crucial for improving the H2 evolution activity of the dye-sensitized semiconductors.

Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity

Chenna, Bala C.,Li, Linfeng,Mellott, Drake M.,Zhai, Xiang,Siqueira-Neto, Jair L.,Calvet Alvarez, Claudia,Bernatchez, Jean A.,Desormeaux, Emily,Alvarez Hernandez, Elizabeth,Gomez, Jana,McKerrow, James H.,Cruz-Reyes, Jorge,Meek, Thomas D.

, p. 3298 - 3316 (2020/04/08)

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacements for the irreversible reactive "warheads" of vinyl sulfone inactivators of cruzain. Peptidomimetic vinyl heterocyclic inhibitors (PVHIs) containing Cbz-Phe-Phe/homoPhe scaffolds with vinyl-2-pyrimidine, vinyl-2-pyridine, and vinyl-2-(N-methyl)-pyridine groups conferred reversible, time-dependent inhibition of cruzain (Ki? = 0.1-0.4 μM). These cruzain inhibitors exhibited moderate to excellent selectivity versus human cathepsins B, L, and S and showed no apparent toxicity to human cells but were effective in cell cultures of Trypanosoma brucei brucei (EC50 = 1-15 μM) and eliminated T. cruzi in infected murine cardiomyoblasts (EC50 = 5-8 μM). PVHIs represent a new class of cruzain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sleeping sickness.

COMPOUNDS AND RELATED COMPOSITIONS AND METHODS OF USE

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Page/Page column 33, (2013/03/26)

Compounds and compositions, which can be use for example, for treating cancer, are described herein.

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