42908-86-1

Basic information

• Product Name: 2-(Chloromethyl)benzoyl chloride
• Synonyms: O-(CHLOROMETHYL)BENZOYL CHLORIDE;2-(Chloromethyl)benzoyl chloride;2-(Chloromethyl)benzoic acid chloride;α-Chloro-o-toluoyl chloride
• CAS NO: 42908-86-1
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.04
• EINECS: 255-998-2
• Mol File: 42908-86-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 17°C(lit.)
• Boiling Point: 265°C(lit.)
• Flash Point: 113.9 °C
• Appearance: COA
• Density: 1.317 g/cm³
• Refractive Index: 1.5760 to 1.5800
• BRN: 1940781
• CAS DataBase Reference: 2-(Chloromethyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Chloromethyl)benzoyl chloride(42908-86-1)
• EPA Substance Registry System: 2-(Chloromethyl)benzoyl chloride(42908-86-1)

Safety Data

• Hazard Codes: T
• Statements: 22-23-34-40
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2927 8(6.1) / PGII
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 42908-86-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 5121, 1973 DOI: 10.1016/S0040-4039(01)87403-7

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 2526-64-9 dichlorotriphenylphosphorane 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 7782-50-5 chlorine 
• 933-88-0 ortho-toluoyl chloride 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 1531-78-8 o-(chloromethyl)benzoic acid ethyl ester 
• 57723-14-5 3-(2-morpholin-4-yl-ethylimino)-4-phenyl-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 
• 57723-19-0 3-benzylimino-4-phenyl-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 
• 57723-18-9 4-benzyl-3-phenylimino-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 
• 57723-20-3 2-benzyl-4-phenyl-3-thioxo-2,3,4,5-tetrahydro-benzo[e][1,3]diazepin-1-one 
• 144782-92-3 methyl 4-(2-((4-fluorophenyl)methyl)benzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate 
• 144782-93-4 methyl 4-<2-(2,5-difluorobenzyl)benzoyl>-2,5-dimethylpyrrole-3-carboxylate 
• 144782-91-2 4-(2-chloromethylbenzoyl)pyrrole 
• 144782-94-5 2,5-Dimethyl-4-[2-(4-methyl-benzyl)-benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester 
• 120934-96-5 methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate 
• 91871-00-0 6-cyano-5-(2-chloromethylbenzoyl)-5,6-dihydrophenanthridine 
• 74133-21-4 2-chloromethylbenzoyl-6,7-dimethoxy-1,2,3,4-tetrahydro isoquinaldonitrile 
• 93290-73-4 2-(2-formyl-4,5-dimethoxyphenylethyl)phthalimidine 
• 93290-74-5 (2-Chloromethyl-phenyl)-(1-hydroxy-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-methanone 

Relevant articles and documents

Kresoxim-methyl Derivatives: Synthesis and Herbicidal Activities of (Pyridinylphenoxymethylene)phenyl Methoxyiminoacetates

A series of new kresoxim-methyl derivatives, (pyridinylphenoxymethylene)phenyl methoxyiminoacetates, were synthesized and their structures were confirmed by NMR and high-resolution mass spectrometry (HRMS). Although derived from a fungicide, the bioassays indicated that several new compounds had good herbicidal activities. At 37.5 g a.i./ha, compound 5c showed 100% inhibition against Abutilon theophrasti, Amaranthus retroflexus, and Eclipta prostrata, which was better than mesotrione. Compound 5e had a broad herbicidal spectrum against broadleaf weeds. The present work indicates that 5c and 5e may serve as new candidates for potential herbicides.

The synthesis of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives

A method for the preparation of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives has been developed. Alkylation of (2,2-dicyano-1-organylaminovinyl)thiolates with methyl 2-(chloromethyl)benzoate or N-substituted 2-(chloromethyl)benzamides with the subsequent treatment of the alkylation products with potassium tert-butoxide gave 3-cyano-2-(organylamino)thieno[3,2-c]isoquinolin-5(4H)-ones. In the case of utilization of (chloromethyl)benzonitrile in this synthesis, 5-amino-3-cyano-2-organylaminothieno[3,2-c]iso-quinolines were obtained.

SGC STIMULATORS

Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.