42974-19-6

Basic information

• Product Name: 1-Benzofuran-2-carbohydrazide, 2-(Hydrazinocarbonyl)-1-benzofuran, 2-(Hydrazinocarbonyl)benzo[b]furan
• Synonyms: 1-Benzofuran-2-carbohydrazide, 2-(Hydrazinocarbonyl)-1-benzofuran, 2-(Hydrazinocarbonyl)benzo[b]furan;Benzo[b]furan-2-carbohydrazide
• CAS NO: 42974-19-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17202
• Mol File: 42974-19-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 190-194 °C
• Appearance: /
• Density: 1.316±0.06 g/cm3(Predicted)
• PKA: 12.27±0.30(Predicted)
• CAS DataBase Reference: 1-Benzofuran-2-carbohydrazide, 2-(Hydrazinocarbonyl)-1-benzofuran, 2-(Hydrazinocarbonyl)benzo[b]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzofuran-2-carbohydrazide, 2-(Hydrazinocarbonyl)-1-benzofuran, 2-(Hydrazinocarbonyl)benzo[b]furan(42974-19-6)
• EPA Substance Registry System: 1-Benzofuran-2-carbohydrazide, 2-(Hydrazinocarbonyl)-1-benzofuran, 2-(Hydrazinocarbonyl)benzo[b]furan(42974-19-6)

Safety Data

• Hazardous Substances Data: 42974-19-6(Hazardous Substances Data)

Usage

Uses

benzofuran-2-carbohydrazide is a small molecule compound used in organic synthesis.

Preparation

Synthesis of benzofuran-2-carbohydrazide: Ethylbenzofuran-2-carboxylate (17.40 g, 0.1 mol) and hydrazine hydrate 99 % (4.8 mL, 0.1 mol) in methanol (35.0 mL) was refluxed for 8 h. The reaction mixture was concentrated and a solid was formed filtered and recrystallized from methanol. The precipitate obtained is benzofuran2-carbohydrazide.

Upstream product

• 1646-27-1 methyl benzofuran-2-carboxylate 
• 41717-28-6 2-benzofuroyl chloride 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 3199-61-9 ethyl coumarilate 
• 90-02-8 salicylaldehyde 

Downstream Products

• 42974-24-3 4-(4-ethoxy-phenyl)-1-(benzofuran-2-carbonyl)-thiosemicarbazide 
• 76268-18-3 C₁₆H₁₄N₂O₄S 
• 1025883-69-5 benzofuro-2-carboxy-(4'-chlorophenyl)thiosemicarbazide 
• 882522-39-6 2-(benzofuran-2-carboxamidylamino)methylphenol 
• 882522-41-0 2-(benzofuran-2-carboxamidylamino)-5-methyl-methylphenol 
• 882522-40-9 2-(benzofuran-2-carboxamidylamino)-5-chloro-methylphenol 
• 1019843-43-6 C₁₇H₁₁ClN₂O₃ 
• 1019843-42-5 C₁₈H₁₄N₂O₄ 
• 1187967-21-0 C₁₆H₉N₃O₄ 
• 1019843-41-4 C₁₈H₁₄N₂O₃ 
• 1019843-40-3 C₁₈H₁₄N₂O₃ 
• 1187967-23-2 C₁₇H₁₁N₃O₅ 
• 1187967-27-6 C₁₈H₁₃ClN₂O₃ 
• 1187967-26-5 C₁₈H₁₃ClN₂O₃ 

Relevant articles and documents

Synthesis, α-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents

A series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2–13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2–13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluated.

Design, Synthesis, Antimicrobial Evaluation, and Laccase Catalysis Effect of Novel Benzofuran–Oxadiazole and Benzofuran–Triazole Hybrids

Novel structural hybrids of benzofuran–oxadiazole and benzofuran–triazole have been synthesized and evaluated for their potential against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. The excellent antibiotic activity was shown by compou

HISTONE DEACETYLASE INHIBITORS AND USES THEREOF

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of cancer.