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Quinidine Methiodide is a metabolite of Quinidine, which is a dextrorotatory stereoisomer of Quinine. It is known for its antiarrhythmic properties as a class IA agent and also serves as an antimalarial compound.

42982-87-6

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  • (S)-[(5R,7R)-5-ethenyl-1-methyl-1-azoniabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol iodide

    Cas No: 42982-87-6

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42982-87-6 Usage

Uses

Used in Pharmaceutical Industry:
Quinidine Methiodide is used as an antiarrhythmic agent for treating various types of abnormal heart rhythms. Its class IA antiarrhythmic action helps stabilize the heart's electrical activity, reducing the risk of life-threatening arrhythmias.
Additionally, Quinidine Methiodide is used as an antimalarial agent for combating malaria infections. Its effectiveness against the Plasmodium parasite contributes to the treatment and prevention of malaria, particularly in regions where the disease is prevalent.

Check Digit Verification of cas no

The CAS Registry Mumber 42982-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,9,8 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 42982-87:
(7*4)+(6*2)+(5*9)+(4*8)+(3*2)+(2*8)+(1*7)=146
146 % 10 = 6
So 42982-87-6 is a valid CAS Registry Number.

42982-87-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-[(2R,5R)-5-ethenyl-1-methyl-1-azoniabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol,iodide

1.2 Other means of identification

Product number -
Other names Methylquinidinium,iodide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42982-87-6 SDS

42982-87-6Downstream Products

42982-87-6Relevant articles and documents

Quaternary salts of alkaloids

Makarevich,Gubin

, p. 473 - 476 (2006)

New biologically active quaternary salts of the alkaloids ajmaline, quinine, hyoscyamine, codeine, and strychnine were synthesized. So-called separable conformers were observed among the ajmaline derivatives.

Modulation of charge transfer by: N -alkylation to control photoluminescence energy and quantum yield

Turley, Andrew T.,Danos, Andrew,Prlj, Antonio,Monkman, Andrew P.,Curchod, Basile F. E.,McGonigal, Paul R.,Etherington, Marc K.

, p. 6990 - 6995 (2020)

Charge transfer in organic fluorophores is a fundamental photophysical process that can be either beneficial, e.g., facilitating thermally activated delayed fluorescence, or detrimental, e.g., mediating emission quenching. N-Alkylation is shown to provide straightforward synthetic control of the charge transfer, emission energy and quantum yield of amine chromophores. We demonstrate this concept using quinine as a model. N-Alkylation causes changes in its emission that mirror those caused by changes in pH (i.e., protonation). Unlike protonation, however, alkylation of quinine's two N sites is performed in a stepwise manner to give kinetically stable species. This kinetic stability allows us to isolate and characterize an N-alkylated analogue of an 'unnatural' protonation state that is quaternized selectively at the less basic site, which is inaccessible using acid. These materials expose (i) the through-space charge-transfer excited state of quinine and (ii) the associated loss pathway, while (iii) developing a simple salt that outperforms quinine sulfate as a quantum yield standard. This N-alkylation approach can be applied broadly in the discovery of emissive materials by tuning charge-transfer states.

Quinine based ionic liquids: A tonic for base instability

McNeice, Peter,Vallana, Federico M.F.,Coles, Simon J.,Horton, Peter N.,Marr, Patricia C.,Seddon, Kenneth R.,Marr, Andrew C.

, (2019/11/26)

Six basic ionic liquids were synthesised from the natural molecule quinine, including one room temperature ionic liquid. The thermal properties were studied and the basicity analysed by Hammett measurements. The properties are discussed in relation to the crystal structure of one of the salts, [C4Qn][NTf2] (2c) and electron density models generated using Spartan. The ionic liquids were shown to catalyse the Knoevenagel condensation of Malononitrile and Benzaldehyde.

Synthesis and characterization of chiral ionic liquids based on quinine, L-proline and L-valine for enantiomeric recognition

Sintra, Tania E.,Gantman, Mikhail G.,Ventura, Sónia P.M.,Coutinho, Jo?o A.P.,Wasserscheid, Peter,Schulz, Peter S.

, p. 410 - 416 (2019/03/28)

The separation of enantiomers remains a major challenge for the pharmaceutical industry. In this work, eight chiral ionic liquids (CILs) directly derived from the ‘chiral pool’ were synthesized and characterized in order to develop enantioselective systems, for the chiral resolution. According to their chiral cations, three different groups of CILs were prepared, namely based on quinine, L-proline and L-valine, and their enantiomeric recognition ability evaluated. For that purpose the diastereomeric interactions between a racemic mixture of Mosher's acid sodium salt and each CIL were studied using 19F NMR spectroscopy. The remarkable chemical shift dispersion induced by some CILs demonstrates their potential application in chiral resolution. Additionally the optical rotation, thermophysical properties and ecotoxicity against the marine bacteria Aliivibrio fischeri of these chiral ionic liquids were addressed.

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