43087-79-2

Basic information

• Product Name: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one
• Synonyms: (4Z)-4-(2,3-Dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one; 4-(2,3-Dimethoxy-benzylidene)-2-phenyl-4H-oxazol-5-one; 5(4H)-Oxazolone, 4-[(2,3-dimethoxyphenyl)methylene]-2-phenyl-, (4Z)-
• CAS NO: 43087-79-2
• Molecular Formula: C₁₈H₁₅NO₄
• Molecular Weight: 309.316
• Mol File: 43087-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 445.2°C at 760 mmHg
• Flash Point: 190.9°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.04E-08mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(43087-79-2)
• EPA Substance Registry System: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(43087-79-2)

Safety Data

• Hazardous Substances Data: 43087-79-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one" is a heterocyclic compound with a specific structure containing a 1,3-oxazol-5(4H)-one ring and a 2,3-dimethoxybenzylidene group. It is classified as an oxazolone, which is a class of organic compounds known for their diverse biological activities. (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one may have potential applications in pharmaceuticals and materials science due to its unique structure and properties. Researchers may be interested in further studying its potential uses and properties in various fields.

Upstream product

• 495-69-2 Hippuric Acid 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 83949-20-6 N^α-benzoyl-2,3-dimethoxydehydrophenylalanylglycine methyl ester 
• 1357516-02-9 (Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one 
• 98833-70-6 α-benzoylamino-2,3-dimethoxy-trans-cinnamic acid 
• 28095-48-9 2-amino-3-(2,3-dihydroxyphenyl)propanoic acid 

Relevant articles and documents

Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones

Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities.