43125-06-0

Basic information

• Product Name: CYCLOHEXYL-2-PHENETHYL KETONE
• Synonyms: CYCLOHEXYL-2-PHENETHYL KETONE
• CAS NO: 43125-06-0
• Molecular Formula: C₁₅H₂₀O
• Molecular Weight: 216.32
• Mol File: 43125-06-0.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 327.6°C at 760 mmHg
• Flash Point: 138.2°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.0002mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: CYCLOHEXYL-2-PHENETHYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYL-2-PHENETHYL KETONE(43125-06-0)
• EPA Substance Registry System: CYCLOHEXYL-2-PHENETHYL KETONE(43125-06-0)

Safety Data

• Hazardous Substances Data: 43125-06-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H20O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1,3-4,7-8,14H,2,5-6,9-12H2

Upstream product

• 43125-15-1 3-phenyl-S-(2'-pyridyl) thiopropionate 
• 931-50-0 cyclohexylmagnesium bromide 
• 3277-89-2 phenethylmagnesium bromide 
• 98-89-5 Cyclohexanecarboxylic acid 
• 3145-73-1 1-cyclohexyl-3-phenylprop-2-en-1-one 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 1539-59-9 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55628-83-6 1-(1H-imidazol-1-yl)-3-phenylpropan-1-one 
• 100-42-5 styrene 
• 2043-61-0 cyclohexanecarbaldehyde 
• 110-82-7 cyclohexane 
• 4354-48-7 2-cyclohexyl-2-oxoacetaldehyde 
• 645-45-4 hydrocinnamic acid chloride 
• 501-52-0 3-Phenylpropionic acid 

Relevant articles and documents

Hydrogen borrowing catalysis using 1° and 2° alcohols: Investigation and scope leading to α and β branched products

The alkylation of a variety of ketones using 1° or 2° alcohols under hydrogen borrowing catalysis is described. Initial research focused on the α-alkylation of cyclopropyl ketones with higher 1° alcohols (i.e. larger than MeOH), leading to the formation of α-branched products. Our search for additional substrates with which to explore this chemistry led us to discover that di-ortho-substituted aryl ketones were also privileged scaffolds, with Ph? (C6Me5) ketones being the optimal choice. Further investigations revealed that this motif was crucial for alkylation with 2° alcohols forming β-branched products, which also provided an opportunity to study diastereoselective and intramolecular hydrogen borrowing processes.

Rapid and Direct Photocatalytic C(sp3)?H Acylation and Arylation in Flow

Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp3)?C(sp2) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12–48 hours to only 5–15 minutes. Finally, kinetic measurements highlight how the intensified conditions do not change the reaction mechanism but reliably speed up the overall process.

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.