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Cas Database

43183-36-4

43183-36-4

Identification

  • Product Name:1H-Benzotriazole,1-(trimethylsilyl)-

  • CAS Number: 43183-36-4

  • EINECS:

  • Molecular Weight:191.308

  • Molecular Formula: C9H13N3Si

  • HS Code:2933990090

  • Mol File:43183-36-4.mol

Synonyms:(1H-Benzotriazol-1-yl)trimethylsilane;1-Trimethylsilyl-1H-benzotriazole;1-Trimethylsilylbenzotriazole;

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Safety information and MSDS view more

  • Pictogram(s):FlammableF, IrritantXi

  • Hazard Codes:F,Xi

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapourH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:1-(Trimethylsilyl)-1H-benzotriazole
  • Packaging:100mg
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:1-(Trimethylsilyl)-1H-benzotriazole >97.0%(GC)
  • Packaging:25g
  • Price:$ 170
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:1-(Trimethylsilyl)-1H-benzotriazole >97.0%(GC)
  • Packaging:5g
  • Price:$ 59
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1-(Trimethylsilyl)-1H-benzotriazole 96%
  • Packaging:5g
  • Price:$ 57.2
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  • Manufacture/Brand:Crysdot
  • Product Description:1-(Trimethylsilyl)-1H-benzo[d][1,2,3]triazole 95+%
  • Packaging:100g
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  • Manufacture/Brand:Chem-Impex
  • Product Description:1-(Trimethylsilyl)-1H-benzotriazole,≥96%(PuritybyGC)Hazmat ≥96%(PuritybyGC)
  • Packaging:1KG
  • Price:$ 1892.8
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-TRIMETHYLSILYL-1H-BENZOTRIAZOLE 95.00%
  • Packaging:25G
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-TRIMETHYLSILYL-1H-BENZOTRIAZOLE 95.00%
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  • Manufacture/Brand:AK Scientific
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Relevant articles and documentsAll total 6 Articles be found

One-pot synthesis of azanucleosides from proline derivatives stereoselectivity in sequential processes

Boto, Alicia,Hernandez, Dacil,Hernandez, Rosendo

experimental part, p. 3847 - 3857 (2010/09/05)

Common amino acid derivatives can be transformed in onestep fashion into N-azanucleosides. The method is a sequential process initiated, by a domino radical decarboxylation/ oxidation reaction; an acyliminium ion is formed as an intermediate and can be trapped by nitrogen bases (purines, pyrimidines, and benzotriazole). The mildness of the reaction conditions and the good, yields obtained make this procedure an interesting alternative to the conventional processes. Good stereoselectivities were obtained with 4-(silyloxy)proline derivatives as substrates.

One-pot synthesis of acyclic nucleosides from carbohydrate derivatives, by combination of tandem and sequential reactions

Boto, Alicia,Hernandez, Dacil,Hernandez, Rosendo,Alvarez, Eleuterio

, p. 9523 - 9532 (2008/03/28)

(Chemical Equation Presented) The design of processes which combine tandem and sequential reactions allows the transformation of readily available precursors into high-profit products. This strategy is illustrated by the one-pot synthesis of acyclic nucle

Chemistry of N,N-bis(silyloxy)enamines: Part 5 - Interaction with N-trialkylsilylated azoles. Convenient method for the synthesis of α-azolyl-substituted oximes

Lesiv, Alexey V.,Ioffe, Sema L.,Strelenko, Yury A.,Tartakovsky, Vladimir A.

, p. 3489 - 3507 (2007/10/03)

Aliphatic nitro compounds can be considered as good precursors of a wide variety of α-azolyl-substituted oximes. The double silylation of convenient aliphatic nitro compounds and the subsequent N,C-coupling of the resulting N,N-bis(silyloxy)enamines 3 with N-silylated azoles 4 lead to the formation of the silylated α-azolylsubstituted oximes 6, which can be smoothly desilylated to give the target α-azolyl-substituted oximes 5. The mechanism of the key step of this process - N,C-coupling - includes the generation of corresponding conjugated nitrosoalkenes 7 (Schemes 4 and 5). The contribution of the chain mechanism in the overall process is considered as well, The studies of the scope and limitations of this reaction, as well as the optimization of its conditions were accomplished. The configuration of the C=N bond in oximes was established by NMR.

ACYCLIC ANALOGS OF NUCLEOSIDES: SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY OF BENZIMIDAZOLES AND BENZOTRIAZOLES

Yavorskii, A. E.,Reshot'ko, L. N.,Kucheryavenko, A. A.,Florent'ev, V. L.

, p. 481 - 486 (2007/10/02)

-

Acyclic Analogs of Nucleosides. Synthesis of Hydroxyalkylbenzimidazoles and -Benzotriazoles

Yavorskii, A. E.,Stetsenko, A. V.,Zavgorodnii, S. G.,Florent'ev, V. L.

, p. 163 - 167 (2007/10/02)

Condensation of trimethylsilyl derivatives of benzimidazole and benzotriazole with alkylating agents in the presence of trimethylsilyl trifluoromethanesulfonate or SnCl4, or direct alkylation of the sodium salts of benzimidazole and benzotriazole, gives 1-(2,3-dihydroxypropyl)-, 1-(3-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, and 1-(1,5-dihydroxy-3-oxapent-2-yl)benzimidazole and -benzotriazole.

Process route upstream and downstream products

Process route

1,2,3-Benzotriazole
95-14-7,27556-51-0

1,2,3-Benzotriazole

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

Conditions
Conditions Yield
With sulfuric acid; heating, few hours;
92.7%
90%
1,2,3-Benzotriazole
95-14-7,27556-51-0

1,2,3-Benzotriazole

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

Conditions
Conditions Yield
at 130 ℃; for 1h;
at 130 ℃; for 1h; Inert atmosphere;
benzoimidazole
51-17-2,79351-71-6

benzoimidazole

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

Conditions
Conditions Yield
With 1,1,1,3,3,3-hexamethyl-disilazane; for 2h; Heating;
1,2,3-Benzotriazole
95-14-7,27556-51-0

1,2,3-Benzotriazole

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

Conditions
Conditions Yield
In various solvent(s); for 2h; Heating;
1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

Conditions
Conditions Yield
Benzotriazol 8a, Hexamethyldisilazan;
Benzotriazol (I), Hexamethyldisilazan;
Benzotriazol, Hexamethylsilazan;
Benzotriazol, 2,3,5-Tri-O-acetyl-D-ribofuranosylbromid;
(yield)95.2percent;
1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

1-methyl-1H-benzo[d][1,2,3]triazole
13351-73-0

1-methyl-1H-benzo[d][1,2,3]triazole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 50 percent / CH2Cl2; toluene / 1 h / Ambient temperature
2: 90 percent / Ambient temperature
3: 71 percent Spectr. / 120 °C / other alkoxycarbonylbenzotriazoles
In dichloromethane; toluene;
Multi-step reaction with 2 steps
1: 90 percent / SO2Cl2 / 0 °C
2: tetrahydrofuran / 24 h / Ambient temperature
With sulfuryl dichloride; In tetrahydrofuran;
4-Methylacetanilide
103-89-9

4-Methylacetanilide

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

1,2-di(benzotriazol-1-yl)-2-[(4-methylphenyl)imino]-1-ethanethione

1,2-di(benzotriazol-1-yl)-2-[(4-methylphenyl)imino]-1-ethanethione

Conditions
Conditions Yield
1-(trimethylsilyl)-1H-benzotriazole; With thionyl chloride; In dichloromethane; at 20 ℃;
4-Methylacetanilide; In dichloromethane; Further stages.; Heating;
86%
N,N'-Diphenyloxamid
620-81-5

N,N'-Diphenyloxamid

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

bis(phenylimidoyl-1-benzotriazole)

bis(phenylimidoyl-1-benzotriazole)

Conditions
Conditions Yield
1-(trimethylsilyl)-1H-benzotriazole; With thionyl chloride; at 20 ℃;
N,N'-Diphenyloxamid; In benzene; for 4h; Further stages.; Heating;
86%
3-Chloroacetanilide
588-07-8

3-Chloroacetanilide

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

1,2-di(benzotriazol-1-yl)-2-[(3-chlorophenyl)imino]-1-ethanethione

1,2-di(benzotriazol-1-yl)-2-[(3-chlorophenyl)imino]-1-ethanethione

Conditions
Conditions Yield
1-(trimethylsilyl)-1H-benzotriazole; With thionyl chloride; In dichloromethane; at 20 ℃;
3-Chloroacetanilide; In dichloromethane; Further stages.; Heating;
88%
1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

2-(1-phenylvinyl)-2H-benzo[d][1,2,3]triazole

2-(1-phenylvinyl)-2H-benzo[d][1,2,3]triazole

Conditions
Conditions Yield
With dipotassium peroxodisulfate; In 1,4-dioxane; at 120 ℃; for 6h;
68%

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