43192-33-2

Basic information

• Product Name: 4-BROMO-2-METHOXYBENZALDEHYDE
• Synonyms: 2-Methoxy-4-broMobenzaldehyde;5-Bromo-2-formylanisole, 4-Bromo-o-anisaldehyde;4-BroMo-2-Methoxybenzaldehyde, 97%+
• CAS NO: 43192-33-2
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.05
• Mol File: 43192-33-2.mol
• Article Data: 24

Chemical Properties

• Melting Point: 67-71 °C
• Boiling Point: 288.106 °C at 760 mmHg
• Flash Point: 128.042 °C
• Appearance: /
• Density: 1.522 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-BROMO-2-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHOXYBENZALDEHYDE(43192-33-2)
• EPA Substance Registry System: 4-BROMO-2-METHOXYBENZALDEHYDE(43192-33-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25
• WGK Germany: 2
• Hazardous Substances Data: 43192-33-2(Hazardous Substances Data)

Usage

Chemical Properties

off-white solid

Uses

Different sources of media describe the Uses of 43192-33-2 differently. You can refer to the following data:
1. 4-Bromo-2-methoxybenzaldehyde is used in the building block, synthesis of a nonacid degradable linker for solid-phase synthesis.
2. Building block in the synthesis of a nonacid degradable linker for solid-phase synthesis.

InChI:InChI=1/C8H7BrO2/c1-11-8-4-7(9)3-2-6(8)5-10/h2-5H,1H3

Upstream product

• 22532-62-3 4-bromosalicylaldehyde 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 2398-37-0 3-methoxyphenyl bromide 
• 4885-02-3 Dichloromethyl methyl ether 
• 330793-38-9 4-bromo-2-methoxybenzonitrile 
• 139102-34-4 methyl 4-bromo-2-methoxybenzoate 
• 591-20-8 3-Bromophenol 
• 95970-08-4 1,4-dibromo-2-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 77-78-1 dimethyl sulfate 
• 17102-63-5 (4-bromo-2-methoxyphenyl)methanol 

Downstream Products

• 99632-51-6 (+/-)-1-(4-bromo-2-methoxyphenyl)-2-aminopropane 
• 139102-26-4 2-(4-bromo-2-methoxyphenyl)aminoethane 
• 1050477-31-0 BAY₉₄₈₈₆₂ 
• 1050477-43-4 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-l,6-naphthyridine-3-carboxylate 
• 1050477-44-5 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate 
• 1050477-45-6 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid 
• 21962-45-8 4-formyl-3-methoxy-benzonitrile 
• 22532-62-3 4-bromosalicylaldehyde 
• 858523-37-2 2-(4-bromo-2-methoxyphenyl)acetonitrile 
• 343603-82-7 3-methoxy-[1,1'-biphenyl]-4-carbaldehyde 
• 1233689-56-9 (E)-3-(4-bromo-2-methoxyphenyl)-1-(2-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 1073612-84-6 C₁₈H₁₁BrF₃NO₂S₂ 
• 1091618-41-5 C₁₀H₈BrNO₂ 
• 956431-01-9 2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde 

Relevant articles and documents

PREPARATION OF A CHK1 INHIBITOR COMPOUND

The invention provides a novel synthetic route for the preparation of the Chk-1 inhibitor compound; also provided by the invention is a novel process for the preparation of the synthetic intermediate of formula (11); as well as novel process intermediates

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND RECOVERY OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE BY ELECTROCHEMICAL METHODS

The present invention relates to a novel process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and recovering (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) proceeding from (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula ent-(I)

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).