4388-18-5

Basic information

• Product Name: Benzenemethanol, a-[[bis(2-hydroxyethyl)amino]methyl]-
• CAS NO: 4388-18-5
• Molecular Formula: C12H19NO3
• Molecular Weight: 225.288
• Mol File: 4388-18-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-[[bis(2-hydroxyethyl)amino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-[[bis(2-hydroxyethyl)amino]methyl]-(4388-18-5)
• EPA Substance Registry System: Benzenemethanol, a-[[bis(2-hydroxyethyl)amino]methyl]-(4388-18-5)

Safety Data

• Hazardous Substances Data: 4388-18-5(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 96-09-3 styrene oxide 
• 111-42-2 2,2'-iminobis[ethanol] 
• 2425-28-7 2-Bromo-1-phenylethanol 

Downstream Products

• 112987-68-5 1-hydroxy-3-phenylgermatrane 
• 594844-99-2 1-hydroxy-4-phenylgermatrane 
• 594845-02-0 O(Ge(OCH₂CH₂)2NCH₂CHC₆H₅O)2 
• 69618-49-1 1-ethyl-3-phenyl-2,8,9-trioxa-5-aza-1-silabicyclo[3,3.3]undecane 
• 919509-29-8 [[1-(2-phenylethanolato)-(1,1',1''-nitrilobis[ethanolato])-(3)-N,O,O',O'']-[1,2,3,4,5-η]cyclopenta-2,4-dien-1-yl]titanium 
• 928853-49-0 4-phenylboratrane 
• 928853-48-9 3-phenylboratrane 
• 594844-97-0 1-chloro-4-phenylgermatrane 
• 594844-96-9 1-chloro-3-phenylgermatrane 
• 594844-98-1 1-(phenylethynyl)-3-phenylgermatrane 
• 113115-99-4 3-phenyl-1-germatranol 
• 112987-68-5 3-phenyl-1-germatranol 
• 76666-28-9 1,3-diphenylgermatrane 
• 23980-79-2 4-[2-Hydroxyethyl]-2-phenylmorpholine hydrochloride 

Relevant articles and documents

Synthesis and characterization of 3- and 4-phenylgermatranes: X-ray crystal structures of N(CH2CH2O) 2(CH2CHPhO)GeZ (Z=F, OSiMe3, C≡CPh) and N(CH2CH2O)2 (CHPhCH2O)GeOH

Reaction of excess of product A [(HOCH2CH2)2NCH2 CH(Ph)OH (1):(HOCH2CH2)2NCH(Ph) CH2OH (2)=9:1] with GeCl4 led to a mixture of 1-chloro-3-phenylgermatrane (3) and 1-chloro-4-phenylgermatrane (4). Compound 4 was isolated in yield 9% from this mixture. Reaction of (EtO)3GeCl with product A gave 3 in yield 55%. 1-(Phenylethynyl)-3-phenylgermatrane (5) was prepared in yield 31% by treatment of (EtO)3GeC≡CPh with product A. Reaction of product A with mixture of GeO2 and H2O produced N(CH2CH2O)2 (CH2CHPhO)GeOH (6) in yield 73%. The presence of N(CH2CH2O)2(CHPhCH2O)GeOH (7) among the products of this reaction was confirmed by 1H-, 13C-NMR spectroscopy and X-ray analysis. N(CH2CH2O)2(CH2CHPhO)GeF (8) is formed by the treatment of 6 with BF3·Et2O. N(CH2CH2O)2(CH2CHPhO) GeOSiMe3 (9) was obtained by silylation of 6 with (Me3Si)2NH or Me3SiCl-Et3N. Refluxing of a suspension of 6 in xylene with continuous removal of water by azeotropic distillation afforded [N(CH2CH2O)2(CH2CHPhO)Ge] 2O (10). 9 reacted with SOCl2, Me3SiBr and Me3SiOTf to give N(CH2CH2O)2(CH2CHPhO)GeX (3, X=Cl; 11, X=Br; 12, X=OTf), respectively. Reaction of 11 with Et3SnOMe led to the formation of N(CH2CH2O)2(CH2CHPhO)GeOMe (13). Germatranes N(CH2CH2O)2 (CH2CHPhO)GeY [14, Y=Flu (fluorenyl); 15, Y=N(SiMe3)2] were obtained from the nucleophilic substitution of the substituent X in N(CH2CH2O) 2(CH2CHPhO)GeX (X=OSiMe3, Br) with the corresponding LiY. All compounds were characterized by 1H- and 13C-NMR spectroscopy and mass spectrometry. Single-crystal structures of 5 and 7-9 were determined by X-ray diffraction studies.