442905-33-1 Usage
Uses
Used in Asymmetric Hydrogenation:
(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine is used as a ligand in asymmetric hydrogenation reactions for the selective reduction of β-keto esters, 2-arylacrylates, aryl ketones, and other substrates. Its unique structure allows for high enantioselectivity and reactivity, making it a preferred choice in the synthesis of chiral compounds with biological and pharmaceutical relevance.
Used in Catalysis:
In the field of catalysis, (R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine is widely used as a catalyst precursor when combined with transition metal complexes such as Rh, Ru, and Ir. The ligand's properties enhance the catalytic activity and selectivity of these metal centers, leading to improved reaction outcomes in various organic transformations.
Used in Pharmaceutical Industry:
(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine is used as a chiral ligand in the synthesis of pharmaceutical compounds, facilitating the production of enantiomerically pure drugs. Its ability to induce high enantioselectivity in catalytic reactions is crucial for the development of single-enantiomer drugs, which can have better efficacy and reduced side effects compared to racemic mixtures.
Used in Fine Chemicals Industry:
In the fine chemicals industry, (R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine is employed as a ligand in the production of enantiomerically pure compounds for use as fragrances, flavors, and other specialty chemicals. The ligand's high selectivity in asymmetric hydrogenation and other catalytic processes ensures the consistent synthesis of high-quality products with desired chiral purity.
Reactions
Chiral ligand for ruthenium- catalyzed asymmetric hydrogenation of aromatic ketones.
Chiral ligand for iridium-catalyzed asymmetric hydrogenation of quinolines.
Chiral ligand for copper- catalyzed asymmetric hydrosilylation of ketones.
Synthesis of new chiral 2-functionized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines.
Rhodium-biphosphine-catalyzed asymmetric, intermolecular hydroheteroarylation of α-substituted acrylate derivatives.
Check Digit Verification of cas no
The CAS Registry Mumber 442905-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,9,0 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 442905-33:
(8*4)+(7*4)+(6*2)+(5*9)+(4*0)+(3*5)+(2*3)+(1*3)=141
141 % 10 = 1
So 442905-33-1 is a valid CAS Registry Number.
442905-33-1Relevant articles and documents
A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters
Wu, Jing,Chen, Hua,Kwok, Wai Him,Lam, Kim Hung,Zhou, Zhong Yuan,Yeung, Chi Hung,Chan, Albert S.C
, p. 1539 - 1543 (2007/10/03)
A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand, Ru(R-Xyl-P-Phos)(C6H6)Cl2, has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of β-ketoesters and shows good potential for industrial applications.
