4432-34-2

Basic information

• Product Name: 2-MORPHOLINO-1-PHENYLETHANOL
• Synonyms: α-Phenyl-4-morpholineethanol;α-Phenylmorpholine-4-ethanol;2-morpholin-4-yl-1-phenylethanol;2-morpholin-4-yl-1-phenyl-ethanol;WLN: T6N DOTJ AYR&1;2-MORPHOLINO-1-PHENYLETHANOL;N(2-HYDROXY-2-PHENYLETHYL) MORPHOLINE;1-(beta-Hydroxyphenethyl)morpholine
• CAS NO: 4432-34-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 4432-34-2.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.6°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 2.98E-05mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 2-MORPHOLINO-1-PHENYLETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINO-1-PHENYLETHANOL(4432-34-2)
• EPA Substance Registry System: 2-MORPHOLINO-1-PHENYLETHANOL(4432-34-2)

Safety Data

• Hazardous Substances Data: 4432-34-2(Hazardous Substances Data)

Usage

General Description

2-MORPHOLINO-1-PHENYLETHANOL is a chemical compound with the molecular formula C10H13NO2. This colorless liquid is commonly used as a reagent in organic synthesis and as a chiral auxiliary in asymmetric synthesis. It is composed of a morpholine ring and a phenylethanol moiety, making it a chiral compound. It can be used as a building block in the synthesis of bioactive compounds and pharmaceuticals due to its ability to act as a versatile intermediate. The compound has been widely studied for its potential applications in the pharmaceutical, agrochemical, and fragrance industries, making it an important and versatile chemical in organic chemistry.

InChI:InChI=1/C12H17NO2/c14-12(11-4-2-1-3-5-11)10-13-6-8-15-9-7-13/h1-5,12,14H,6-10H2/t12-/m1/s1

Upstream product

• 110-91-8 morpholine 
• 96-09-3 styrene oxide 
• 64-17-5 ethanol 
• 66502-26-9 2-morpholino-1-phenyl-ethanone; hydrochloride 
• 779-53-3 4-morpholinylacetophenone 
• 100-42-5 styrene 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 93-56-1 phenylethane 1,2-diol 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 131-36-2 2-naphthalen-1-yl-propionic acid 2-morpholin-4-yl-1-phenyl-ethyl ester 
• 130-32-5 2-naphthalen-1-yl-butyric acid 2-morpholin-4-yl-1-phenyl-ethyl ester 
• 102424-38-4 4-(2-phenoxaborin-10-yloxy-2-phenyl-ethyl)-morpholine 
• 6962-38-5 1-Phenyl-2-morpholino-ethanol-(1)-methoiodid 
• 14746-42-0 N-(2-hydroxy-2-phenylethyl)morpholine N-oxide 
• 100141-00-2 4-(2-bromo-2-phenyl-ethyl)-morpholine 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (S)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (R)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 110-91-8 morpholine 
• 100-52-7 benzaldehyde 
• 50-00-0 formaldehyd 
• 40116-78-7 (R)-2-morpholino-1-phenylethanol 
• 87837-32-9 (S)-2-(morpholin-1-yl)-1-phenylethanol 

Relevant articles and documents

Synthesis of phenylthioacetomorpholide: Effect of substrate on the Willgerodt-Kindler reaction

The effect of substrates on the Willgerodt-Kindler reaction was studied. The existence of acidic protons on these substrates accerelates the formation of thiomorpholide was found.

Tb2(WO4)3@N-GQDs-FA as an efficient nanocatalyst for the efficient synthesis of β-aminoalcohols in aqueous solution

In the current study, Tb2(WO4)3@N-(GQDs) modified with folic acid (FA) was synthesized during the chemical reaction of terbium (III) tungstate nanoparticles with nitrogen doped graphene quantum dots (N-GQDs) and introduced

Highly regioselective ring-opening of epoxides with amines: A metal- A nd solvent-free protocol for the synthesis of β-amino alcohols

We herein report a metal- A nd solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.

Terbium–organic framework as heterogeneous Lewis acid catalyst for β-aminoalcohol synthesis: Efficient, reusable and green catalytic method

A terbium–organic framework (Tb-MOF) was prepared using a previously reported procedure. Tb-MOF was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction and surface area analysis. Tb-MOF was e