446-36-6

Basic information

• Product Name: 5-Fluoro-2-nitrophenol
• Synonyms: 2-Nitro-5-Fluorophenol;5-Fluoro-2-nitrophenol,98%;5-Fluoro-2-nitrophenol 99%;5-Fluoro-2-nitrophenol99%;5-FLUORO-2-NITROPHENOL,2-NITRO-5-FLUOROPHENOL;PHENOL,5-FLUORO-2-NITRO;6-Nitro-3-fluorophenol;4-Fluoro-2-hydroxynitrobenzene
• CAS NO: 446-36-6
• Molecular Formula: C₆H₄FNO₃
• Molecular Weight: 157.1
• EINECS: 207-168-6
• Product Categories: blocks;FluoroCompounds;NitroCompounds;Aromatic Phenols;Benzene series;Phenol&Thiophenol&Mercaptan;Fluorobenzene;Organic Building Blocks;Oxygen Compounds;Phenols;Alphabetic;F;FA - FLOrganic Building Blocks
• Mol File: 446-36-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 260°C
• Flash Point: 197 °F
• Appearance: yellow/Powder, Crystals or Crystalline Mass and/or Chunks
• Density: 1.4306 (estimate)
• Vapor Pressure: 0.0486mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.18±0.13(Predicted)
• Water Solubility: slightly soluble
• BRN: 1870311
• CAS DataBase Reference: 5-Fluoro-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-nitrophenol(446-36-6)
• EPA Substance Registry System: 5-Fluoro-2-nitrophenol(446-36-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-36-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

5-Fluoro-2-nitrophenol has been used in:total synthesis of the (+/?)-CC-1065 CPI subunitsynthesis of 2-(7-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-2H-isoindoline-1,3-diones7-substituted 2H-1,4-benzoxazin-3-(4H)-ones, possessing therapeutic potential as inhibitors of angiogenesis

InChI:InChI=1/C6H4FNO3/c7-4-1-2-5(8(10)11)6(9)3-4/h1-3,9H/p-1

Upstream product

• 372-20-3 3-fluorophenol 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 2369-11-1 5-fluoro-2-nitroaniline 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 7631-86-9 SiO₂ 

Downstream Products

• 395-83-5 3-nitro-benzenesulfonic acid-(5-fluoro-2-nitro-phenyl ester) 
• 157831-78-2 3-fluoro-6-nitro-2,4-bis(piperidin-1'-ylmethyl)phenol 
• 143915-27-9 1-(2-Nitro-5-fluorophenoxy)-2-(CBZ-2-aminoethoxy)ethane 
• 53981-24-1 2-amino-5-fluorophenol 
• 188407-79-6 2-(5-Fluoro-2-nitro-phenoxy)-2-methyl-malonic acid dimethyl ester 
• 28987-46-4 4-fluoro-1-nitro-2-(propan-2-yloxy)benzene 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 367-32-8 4-fluoropyrocatechol 
• 361-48-8 3-fluoro-2,6-dinitro-phenol 
• 367-82-8 3-Fluoro-4,6-dinitrophenol 
• 361-45-5 3-fluoro-2,4,6-trinitro-phenol 
• 129464-01-3 2-(benzyloxy)-4-fluoro-1-nitrobenzene 
• 191096-37-4 dihydro-3-(5-fluoro-2-nitrophenoxy)-2(3H)-furanone 
• 851190-65-3 2-methyl-2-(5-fluoro-2-nitrophenoxy)propionic acid ethyl ester 

Relevant articles and documents

Production process of flumioxazin herbicide

The invention discloses a production process of a flumioxazin herbicide. The process is characterized by comprising the following steps: S1, synthesizing 2-nitro-5-fluorophenol; S2, synthesizing ethyl 2-(5-fluoro-2-nitrophenoxy) acetate; S3, synthesizing 7-fluoro-2H-1, 4-benzoxazine-3 (4H)-ketone; S4, synthesizing 7-fluoro-6-nitro-2H-1, 4-benzoxazine-3 (4H)-ketone; S5, synthesizing 7-fluoro-6-amino-2H-1, 4-benzoxazine-3 (4H)-ketone; S6, synthesizing 7-fluoro-6-(3, 4, 5, 6-tetrahydro)phthalimido-1, 4-benzoxazine-3 (4H) ketone; and S7, synthesizing the flumioxazin. The method has the advantages of low raw material price, few byproducts and light pollution.

5-fluoro-2-nitrophenol preparation method

The invention belongs to the field of organic synthesis, and particularly relates to a 5-fluoro-2-nitrophenol preparation method. In the prior art, the existing synthesis method has disadvantages of low conversion rate and long reaction time so as not to easily achieve industrial operation. A purpose of the present invention is to solve the technical problem in the prior art. The technical schemeis to provide a 5-fluoro-2-nitrophenol preparation method, which comprises: a) carrying out a reaction on 2,4-difluoronitrobenzene and NH 3 to obtain 5-fluoro-2-nitroaniline; and b) carrying out a reaction on the 5-fluoro-2-nitroaniline under the actions of sulfuric acid and sodium nitrite to obtain the 5-fluoro-2-nitrophenol. According to the present invention, the 5-fluoro-2-nitrophenol preparation method has advantages of good selectivity, almost no side reaction, high yield, short reaction time, simple operation and easy industrialization.

Preparation method of Anacetrapib key intermediate

The invention relates to a preparation method of an Anacetrapib key intermediate 1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene. The preparation method comprises the following steps: hydrolyzing an initial raw material 2,4-difluoronitrobenzene to obtain 4-fluoro-2-hydroxynitrobenzene, methylating 4-fluoro-2-hydroxynitrobenzene to obtain 4-fluoro-2-methoxynitrobenzene, carrying out nitro group reduction to form 4-fluoro-2-methoxyaniline, carrying out diazo bromination to obtain 4-fluoro-2-methoxybromobenzene, carrying out Friedel-Crafts acylation to obtain 2-fluoro-4-methoxy-5-bromoacetophenone, carrying out a condensation reaction to obtain 2-(2-fluoro-4-methoxy-5-bromophenyl)-propane-2-ol, carrying out an elimination reaction to obtain 1-bromo-4-fluoro-2-methoxy-5-(1-methylvinyl)benzene, and hydrogenating the 1-bromo-4-fluoro-2-methoxy-5-(1-methylvinyl)benzene to obtain 1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene. The preparation method has the advantages of realization of low cost, good quality and high yield of the above final product, mild reaction conditions, simplicity in operation, and easiness in industrialization.