446-57-1

Basic information

• Product Name: 2,3-DIFLUOROBENZYL CHLORIDE
• Synonyms: 2,3-DIFLUOROBENZYL CHLORIDE;2,3-Difluorobenzyl chloride/alpha-Chloro-2,3-difluorotoluene;2,3-diifluorobenzyl chloride
• CAS NO: 446-57-1
• Molecular Formula: C₇H₅ClF₂
• Molecular Weight: 162.56
• Mol File: 446-57-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 176.2 °C at 760 mmHg
• Flash Point: 62.787 °C
• Appearance: /
• Density: 1.295 g/cm³
• Vapor Pressure: 1.49mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,3-DIFLUOROBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUOROBENZYL CHLORIDE(446-57-1)
• EPA Substance Registry System: 2,3-DIFLUOROBENZYL CHLORIDE(446-57-1)

Safety Data

• Hazardous Substances Data: 446-57-1(Hazardous Substances Data)

Usage

General Description

2,3-Difluorobenzyl chloride is an organic compound with the chemical formula C7H5ClF2. It is a clear, colorless liquid that is widely used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is commonly employed as a benzyl protecting group in organic synthesis reactions, as well as a building block for the production of fluorinated compounds. It is a highly reactive compound and must be handled with caution due to its potential to cause skin and eye irritation, as well as respiratory and digestive tract discomfort. Overall, 2,3-difluorobenzyl chloride plays a crucial role in the production of numerous important chemicals in various industries.

InChI:InChI=1/C7H5ClF2/c8-4-5-2-1-3-6(9)7(5)10/h1-3H,4H2

Upstream product

• 75853-18-8 (2,3-difluoro-phenyl)-methanol 
• 2646-91-5 2,3-difluorobenzaldehyde 
• 367-11-3 ortho-difluorobenzene 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 

Downstream Products

• 380424-27-1 1-(2,3-difluoro-benzyl)-piperidine-4-carboxylic acid amide 
• 1985605-59-1 (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 2136287-66-4 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 1352146-17-8 C₃₁H₂₉F₂N₅O 
• 380426-23-3 2-chloro-6-[4-[1-(2,3-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine 
• 380424-77-1 4-amino-1-(2,3-difluorobenzyl)piperidine 

Relevant articles and documents

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.