Welcome to LookChem.com Sign In|Join Free

CAS

  • or

4463-31-4

Post Buying Request

4463-31-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

4463-31-4 Usage

General Description

1-(chloromethyl)-4-cyclohexylbenzene is a chemical compound with the molecular formula C13H17Cl. It is a chloromethyl derivative of cyclohexylbenzene, which is commonly used as a solvent, intermediate in organic synthesis and for the production of resins and polymers. The chloromethyl group is a functional group consisting of a methyl group bound to a chlorine atom, making the compound a reactive intermediate in organic chemistry. 1-(chloromethyl)-4-cyclohexylbenzene has a wide range of potential applications in the pharmaceutical, agrochemical, and material science industries, making it an important target for chemical synthesis and research.

Check Digit Verification of cas no

The CAS Registry Mumber 4463-31-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,6 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4463-31:
(6*4)+(5*4)+(4*6)+(3*3)+(2*3)+(1*1)=84
84 % 10 = 4
So 4463-31-4 is a valid CAS Registry Number.

4463-31-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-chloromethyl-4-cyclohexylbenzene

1.2 Other means of identification

Product number -
Other names 4-cicloesil-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4463-31-4 SDS

4463-31-4Relevant articles and documents

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors

Brotherton-Pleiss, Christine,Yue, Peibin,Zhu, Yinsong,Nakamura, Kayo,Chen, Weiliang,Fu, Wenzhen,Kubota, Casie,Chen, Jasmine,Alonso-Valenteen, Felix,Mikhael, Simoun,Medina-Kauwe, Lali,Tius, Marcus A.,Lopez-Tapia, Francisco,Turkson, James

, p. 695 - 710 (2021/01/14)

We optimized our previously reported proline-based STAT3 inhibitors into an exciting new series of (R)-azetidine-2-carboxamide analogues that have sub-micromolar potencies. 5a, 5o, and 8i have STAT3-inhibitory potencies (IC50) of 0.55, 0.38, and 0.34 μM, respectively, compared to potencies greater than 18 μM against STAT1 or STAT5 activity. Further modifications derived analogues, including 7e, 7f, 7g, and 9k, that addressed cell membrane permeability and other physicochemical issues. Isothermal titration calorimetry analysis confirmed high-affinity binding to STAT3, with KD of 880 nM (7g) and 960 nM (9k). 7g and 9k inhibited constitutive STAT3 phosphorylation and DNA-binding activity in human breast cancer, MDA-MB-231 or MDA-MB-468 cells. Furthermore, treatment of breast cancer cells with 7e, 7f, 7g, or 9k inhibited viable cells, with an EC50 of 0.9-1.9 μM, cell growth, and colony survival, and induced apoptosis while having relatively weaker effects on normal breast epithelial, MCF-10A or breast cancer, MCF-7 cells that do not harbor constitutively active STAT3.

Structure-activity relationship study of E6 as a novel necroptosis inducer

Mou, Jianfeng,Park, Ann,Cai, Yu,Yuan, Junying,Yuan, Chengye

supporting information, p. 3057 - 3061 (2015/06/22)

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.

NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS

-

, (2009/10/22)

The present invention relates to the novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of metabolic disorders.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 4463-31-4