4472-45-1

Basic information

• Product Name: 4-CHLORO-2,6-DIMETHYLPYRIMIDINE
• Synonyms: ASISCHEM A63094;4-CHLORO-2,6-DIMETHYLPYRIMIDINE;TIMTEC-BB SBB010291;Pyrimidine, 4-chloro-2,6-dimethyl- (7CI,8CI,9CI);4-Chloro-2,6-dimethylpyrimidine95%;4-CHLORO-2,6-DIMETHYLPYRIMIDINE 95%;2,4-Dimethyl-6-chloropyrimidine;6-Chloro-2,4-dimethylpyrimidine
• CAS NO: 4472-45-1
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: PYRIMIDINE;API intermediates;Heterocycle-Pyrimidine series;alkyl chloride
• Mol File: 4472-45-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 39-40 °C
• Boiling Point: 197.507 °C at 760 mmHg
• Flash Point: 91.285 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.531mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.19±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-2,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2,6-DIMETHYLPYRIMIDINE(4472-45-1)
• EPA Substance Registry System: 4-CHLORO-2,6-DIMETHYLPYRIMIDINE(4472-45-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 4472-45-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-2,6-dimethylpyrimidine is a chemical compound that is used in various industrial applications and organic synthesis. It is a pyrimidine derivative with a chlorine atom at the 4-position and two methyl groups at the 2 and 6 positions. 4-CHLORO-2,6-DIMETHYLPYRIMIDINE is commonly utilized in the pharmaceutical industry for the synthesis of various drugs, including antiviral and antifungal agents. It is also used as a building block in the production of agrochemicals, dyes, and other fine chemicals. Additionally, 4-Chloro-2,6-dimethylpyrimidine is a versatile intermediate in organic synthesis and can serve as a precursor for the modification of other molecules to create new chemical compounds with different properties and applications.

InChI:InChI=1/C6H7ClN2/c1-4-3-6(7)9-5(2)8-4/h3H,1-2H3

Upstream product

• 930-62-1 2,4-Dimethylimidazole 
• 67-66-3 chloroform 
• 930-61-0 2,4-dimethyl-2-imidazoline 

Downstream Products

• 461-98-3 4-amino-2,6-dimethylpyrimidine 
• 14331-54-5 2,4-dimethylpyrimidine 
• 89808-18-4 4-Hydroxyamino-2,6-dimethylpyrimidine 
• 6622-92-0 2,6-dimethyl-1H-pyrimidin-4-one 
• 66298-42-8 2,4-dimethyl-6-phenylethynyl-pyrimidine 
• 77752-56-8 2,6-dimethyl-4-(phenylthio)pyrimidine 
• 128381-48-6 1-(4-Ethoxy-phenyl)-ethanone O-(2,6-dimethyl-pyrimidin-4-yl)-oxime 
• 128381-47-5 1-(4-Chloro-phenyl)-ethanone O-(2,6-dimethyl-pyrimidin-4-yl)-oxime 
• 128402-31-3 1-(4-Bromo-phenyl)-ethanone O-(2,6-dimethyl-pyrimidin-4-yl)-oxime 
• 128381-46-4 1-Phenyl-ethanone O-(2,6-dimethyl-pyrimidin-4-yl)-oxime 
• 64571-30-8 2,4-dimethyl-6-phenylpyrimidine 
• 127588-28-7 2,4-Dimethyl-6-vinyl-pyrimidine 
• 14331-56-7 4-hydrazinyl-2,6-dimethylpyrimidine 
• 14001-62-8 6-methoxy-2,4-dimethylpyrimidine 

Relevant articles and documents

Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

1-Unsubstituted imidazoles and chloroform at 550 deg C in a flow system give mainly 5-chloropyrimidines, together with 4-chloropyrimidines and chloropyrazines.The effects of methyl substituents on the ratio of products is considered.The liquid-phase reactions of 2-methyl- and 2,4,5-trimethyl-imidazole under conditions in which dichlorocarbene is said to be formed in basic or neutral conditions were studied, and compared with the gas-phase reactions with chloroform.