451447-65-7

Basic information

• Product Name: 4-α-[2-chloroacetate]podophyllotoxin
• Synonyms: 4-α-[2-chloroacetate]podophyllotoxin
• CAS NO: 451447-65-7
• Molecular Weight: 490.894
• Mol File: 451447-65-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-α-[2-chloroacetate]podophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-α-[2-chloroacetate]podophyllotoxin(451447-65-7)
• EPA Substance Registry System: 4-α-[2-chloroacetate]podophyllotoxin(451447-65-7)

Safety Data

• Hazardous Substances Data: 451447-65-7(Hazardous Substances Data)

Upstream product

• 79-11-8 chloroacetic acid 
• 518-28-5 podofilox 
• 79-04-9 chloroacetyl chloride 
• 541-88-8 Chloroacetic anhydride 

Downstream Products

• 122146-76-3 1-[(5aR)-8-oxo-9c-(3,4,5-trimethoxy-phenyl)-(5a#r,8at)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5c-yloxycarbonylmethyl]-pyridinium; chloride 

Relevant articles and documents

Novel hybrids of podophyllotoxin and formononetin inhibit the growth, migration and invasion of lung cancer cells

In this study, three hybrids of podophyllotoxin and formononetin were synthesized and evaluated for anticancer efficacy. Some of the derivatives exhibited potent cytotoxicity against a panel of human and mouse cancer cell lines, with IC50 value

Novel isatin derivatives of podophyllotoxin: Synthesis and cytotoxic evaluation against human leukaemia cancer cells as potent anti-MDR agents

Multidrug resistance (MDR) is a major cause of chemotherapy failure in cancer therapy. In this study, a series of isatin derivatives of podophyllotoxin were synthesized and evaluated for their cytotoxic activity against human leukemia K562 cells and adriamycin-resistant K562/ADR cells using CCK-8 assay in vitro. All derivatives exhibited higher potency of antiproliferative effects against K562 and K562/ADR cell lines than the control drugs etoposide and adriamycin at nanomolar range, and markedly reduced the resistant factors. Among them, the cytotoxicities exhibited by compounds 8c and 8i were found to comparable or more effective than podophyllotoxin. In particular, 8c exhibited significant cytotoxicity against resistance K562/ADR cells with IC50 value of 0.067 ± 0.010 μM. Furthermore, cell cycle analysis revealed that 8c could remarkably induce K562/ADR cell cycle arrest in the G2/M phase. Meanwhile, the effect of 8c on apoptosis inducing was also observed notably by flow cytometry and Hoechst 33342 staining. Moreover, western blotting analysis suggested that 8c had the potential to overcome the resistance of K562/ADR cells by down-regulating the expression levels of multi-drug resistance-related proteins, such as Pgp, MRP-1 and GST-π.

Application of podophyllotoxin isatin derivative to anti-leukemia drug and preparation method for podophyllotoxin isatin derivative

The invention discloses a podophyllotoxin isatin derivative as shown in a formula (I) which is described in the specification. The invention also discloses a preparation method for the derivative and application of the derivative to preparation of an anti