45695-56-5

Basic information

• Product Name: 2-Pyrimidinecarboximidamide (9CI)
• Synonyms: 2-Pyrimidinecarboximidamide (9CI);pyrimidine-2-carboxamidine;2-AMIDINOPYRIMIDINE;2-Pyrimidinecarboximidamide;pyrimidine-2-carboximidic acid amide;2-pyrimidinecarboximidamide(SALTDATA: FREE);Pyrimidine-2-carboximidamide, 2-(Carbamimidoyl)-1,3-diazine
• CAS NO: 45695-56-5
• Molecular Formula: C₅H₆N₄
• Molecular Weight: 122.12794
• Product Categories: PYRIMIDINE
• Mol File: 45695-56-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-126℃
• Boiling Point: 287.4±23.0℃ (760 Torr)
• Flash Point: 127.6±22.6℃
• Appearance: /
• Density: 1.39±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Pyrimidinecarboximidamide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinecarboximidamide (9CI)(45695-56-5)
• EPA Substance Registry System: 2-Pyrimidinecarboximidamide (9CI)(45695-56-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 45695-56-5(Hazardous Substances Data)

Usage

General Description

2-Pyrimidinecarboximidamide (9CI) is a chemical compound with the formula C5H5N3. It is a derivative of pyrimidine with a carboximidamide functional group. 2-Pyrimidinecarboximidamide (9CI) is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other chemical compounds. It has also been studied for its potential use as an antitumor and antiviral agent. Additionally, 2-Pyrimidinecarboximidamide (9CI) has been reported to have herbicidal and insecticidal properties, making it a versatile compound with potential applications in a variety of industries.

Upstream product

• 14080-23-0 2-cyanopyrimidine 
• 4039-32-1 lithium hexamethyldisilazane 
• 38275-60-4 5-bromo-pyrimidine-2-carboxylic acid amide 
• 88511-48-2 pyrimidine-2-carboxamide 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 

Downstream Products

• 1187991-04-3 4-hydroxy-N-(2-phenylpropan-2-yl)-[2,2′-bipyrimidine]-5-carboxamide 
• 3739-82-0 2-ethoxy-pyrimidine 
• 1446680-74-5 methyl 6-chloro-4-(3,4-difluorophenyl)-4-methyl-2-(pyrimidin-2-yl)-1,4-dihydropyrimidine-5-carboxylate 
• 1426140-17-1 1-phenyl-6-(phenylamino)-4-(pyrimidin-2-yl)-1,3,5-triazine-2(1H)-thione 
• 1426140-77-3 C₁₉H₁₂Cl₂N₆S 
• 34671-83-5 2,2'-Bipyrimidine 
• 438249-96-8 2-(2-pyrimidinyl)-6-trifluoromethylpyrimidin-4-ol 

Relevant articles and documents

Elucidating the elusive crystal structure of 2,4,6-tris(2-pyrimidyl)-1,3,5-triazine

2,4,6-Tris(2-pyrimidyl)-1,3,5-triazine (TPymT) has been synthesized using two approaches: via trimerization of 2-cyanopyrimidine at 160 °C and by the reaction of 2-cyanopyrimidine with pyrimidine-2-carboximidamide. It was found that the two different synthetic pathways to TPymT yielded either a single polymorph or a mixture of two polymorphs; both of which were studied for the first time by X-ray powder diffraction (XRPD) and synchrotron X-ray powder diffraction (SXRPD). The crystal structure of the polymorph α-TPymT was determined by single crystal X-ray diffraction (SCXRD). Crystal structures of 2-cyanopyrimidine and pyrimidine-2-carboximidamide were also elucidated by SXRPD.

Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.