458566-84-2

Basic information

• Product Name: 4,4-DIFLUOROCYCLOHEXANAMINE
• Synonyms: 4,4-DIFLUOROCYCLOHEXANAMINE;CYCLOHEXANAMINE, 4,4-DIFLUORO-;4,4-difluorocyclohexan-1-amine
• CAS NO: 458566-84-2
• Molecular Formula: C₆H₁₁F₂N
• Molecular Weight: 135.16
• Product Categories: Pharmaceutical intermediate
• Mol File: 458566-84-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 141℃
• Flash Point: 40℃
• Appearance: /
• Density: 1.08
• PKA: 9.86±0.70(Predicted)
• CAS DataBase Reference: 4,4-DIFLUOROCYCLOHEXANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIFLUOROCYCLOHEXANAMINE(458566-84-2)
• EPA Substance Registry System: 4,4-DIFLUOROCYCLOHEXANAMINE(458566-84-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 458566-84-2(Hazardous Substances Data)

Usage

General Description

4,4-Difluorocyclohexanamine is a chemical compound with the molecular formula C6H12F2N. It is a cyclohexane derivative with two fluorine atoms attached to the fourth carbon of the cyclohexane ring, and an amine group attached to the same carbon. 4,4-Difluorocyclohexanamine is used in organic synthesis as a building block for the construction of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the manufacturing of specialty chemicals and is a valuable tool for medicinal and agricultural research. 4,4-Difluorocyclohexanamine is considered to be a moderately hazardous chemical and must be handled with appropriate safety precautions.

Upstream product

• 122665-97-8 4,4-difluorocyclohexanecarboxylic acid 
• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 675112-67-1 tert-butyl (4,4-difluorocyclohexyl)carbamate 
• 810675-56-0 C₁₄H₁₇F₂NO₂ 

Downstream Products

• 810675-56-0 C₁₄H₁₇F₂NO₂ 
• 1198103-23-9 2-(4,4-difluorocyclohexyl)-N-[1-(5-methyl-2-thienyl)ethyl]-3-oxoisoindoline-1-carboxamide 

Relevant articles and documents

Decarboxylative Amination: Diazirines as Single and Double Electrophilic Nitrogen Transfer Reagents

The ubiquity of nitrogen-containing small molecules in medicine necessitates the continued search for improved methods for C-N bond formation. Electrophilic amination often requires a disparate toolkit of reagents whose selection depends on the specific structure and functionality of the substrate to be aminated. Further, many of these reagents are challenging to handle, engage in undesired side reactions, and function only within a narrow scope. Here we report the use of diazirines as practical reagents for the decarboxylative amination of simple and complex redox-active esters. The diaziridines thus produced are readily diversifiable to amines, hydrazines, and nitrogen-containing heterocycles in one step. The reaction has also been applied in fluorous phase synthesis with a perfluorinated diazirine.

COMPOUNDS AND THERAPEUTIC USES THEREOF

The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.

GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.