459-23-4

Basic information

• Product Name: 4-FLUOROBENZALDEHYDE OXIME
• Synonyms: p-fluorobenzaldehydeoxime;p-fluoro-benzaldehydoxime;4-FLUOROBENZALDOXIME;4-FLUOROBENZALDEHYDE OXIME;syn-4-fluorobenzaldoxime;4-FLUOROBENZALDEHYDE OXIME(WX690078);Benzaldehyde, p-fluoro-, oxime
• CAS NO: 459-23-4
• Molecular Formula: C₇H₆FNO
• Molecular Weight: 139.13
• EINECS: 209-628-1
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 459-23-4.mol
• Article Data: 140

Chemical Properties

• Melting Point: 82-85 °C(lit.)
• Boiling Point: 194.9 °C at 760 mmHg
• Flash Point: 71.7 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.27mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: 2-8°C
• PKA: 10.58±0.10(Predicted)
• CAS DataBase Reference: 4-FLUOROBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZALDEHYDE OXIME(459-23-4)
• EPA Substance Registry System: 4-FLUOROBENZALDEHYDE OXIME(459-23-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: CU6260000
• Hazardous Substances Data: 459-23-4(Hazardous Substances Data)

Usage

General Description

4-Fluorobenzaldehyde oxime is a chemical compound with the molecular formula C7H7FNO. It is an oxime derivative of 4-fluorobenzaldehyde and is commonly used in organic synthesis and pharmaceutical research. 4-Fluorobenzaldehyde oxime has a variety of applications, including as a starting material for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the production of dyes, pigments, and other chemical products. The compound is known for its ability to undergo various chemical reactions, making it a versatile building block for the preparation of diverse chemical compounds.

InChI:InChI=1/C7H6FNO/c8-7-3-1-6(2-4-7)5-9-10/h1-5,10H/b9-5+

Upstream product

• 140-75-0 para-fluorobenzylamine 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 588-95-4 syn-4-fluorobenzaldoxime 
• 459-57-4 4-fluorobenzaldehyde 
• 352-32-9 p-fluorotoluene 
• 459-56-3 4-fluorobenzylic alcohol 
• 79-24-3 Nitroethane 
• 462-06-6 fluorobenzene 
• 75-52-5 nitromethane 
• 96-29-7 ethyl methyl ketone oxime 
• 459-46-1 4-Fluorobenzyl bromide 
• 18539-44-1 (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran 
• 14629-55-1 (4-fluorobenzyloxy)trimethylsilane 

Downstream Products

• 206055-89-2 3-(4-fluorophenyl)-5-hydroxymethylisoxazole 
• 472976-35-5 3-p-fluorophenyl-5-hydroxymethyl-Δ²-isoxazoline 
• 42202-95-9 4-fluoro-N-hydroxybenzimidoyl chloride 
• 1194-02-1 4-fluorobenzonitrile 

Relevant articles and documents

Nickel-Catalyzed NO Group Transfer Coupled with NOxConversion

Nitrogen oxide (NOx) conversion is an important process for balancing the global nitrogen cycle. Distinct from the biological NOx transformation, we have devised a synthetic approach to this issue by utilizing a bifunctional metal catalyst for producing value-added products from NOx. Here, we present a novel catalysis based on a Ni pincer system, effectively converting Ni-NOx to Ni-NO via deoxygenation with CO(g). This is followed by transfer of the in situ generated nitroso group to organic substrates, which favorably occurs at the flattened Ni(I)-NO site via its nucleophilic reaction. Successful catalytic production of oximes from benzyl halides using NaNO2 is presented with a turnover number of >200 under mild conditions. In a key step of the catalysis, a nickel(I)-?NO species effectively activates alkyl halides, which is carefully evaluated by both experimental and theoretical methods. Our nickel catalyst effectively fulfills a dual purpose, namely, deoxygenating NOx anions and catalyzing C-N coupling.

COMPOUNDS AS CASEIN KINASE INHIBITORS

Provided are novel casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also provided.

On the mixed oxides-supported niobium catalyst towards benzylamine oxidation

A series of mixed oxides-supported niobium-based catalysts has been synthesized and applied towards oxidation reactions of benzylamine derivatives. Under the optimized reaction conditions, the selectivity to oxime enhanced, leading to the main product with up to 72 %. Moreover, even α-substituted benzylamines were well tolerated and led to oximes in good isolated yields. It is important to mention; four equivalents of the harmless and inexpensive hydrogen peroxide were employed as oxidizing agent. Mechanism hypothesis suggested that the reaction proceed to selective benzylamine oxidation into nitroso intermediate, following by formation of the corresponding oxime tautomer mediated by an unstable water produced by NbOx supported catalyst. This consists the first mixed oxides-supported niobium-based catalyst for selective oxidation of benzylamines to oximes.