4595-60-2Relevant articles and documents
Synthesis method of 2-bromopyrimidine
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Paragraph 0011; 0035-0043, (2021/10/30)
The invention discloses a synthesis method of 2-bromopyrimidine, the route of which is shown as follows: the synthesis method of 2-bromopyrimidine provided by the invention comprises the following steps: carrying out oxidative addition on carbon-chlorine bonds of 2-chloropyrimidine through a metal catalyst, and then carrying out halogen exchange and reduction elimination to obtain the product 2-bromopyrimidine, and the reaction has the advantages of high operability, environment friendliness, convenience in regulation and control and the like.
Silyl-mediated halogen/halogen displacement in pyridines and other heterocycles
Schlosser, Manfred,Cottet, Fabrice
, p. 4181 - 4184 (2007/10/03)
Heating with bromotrimethylsilane converts 2-chloropyridine into 2-bromopyridine and 2-chloro-6-methylpyridine into 2-bromo-6-methylpyridine. Both 2-chloropyridines and 2-bromopyridines give the corresponding iodo compound when treated with in situ generated iodotrimethylsilane. Although 3- and 4-chloropyridine are completely inert, 2,4-dichloropyridine undergoes the halogen/halogen exchange simultaneously at the 2- and 4-position. Halogen displacement takes place exclusively at the 2-position with 2,3-dichloropyridine and 2,5-dichloropyridine. In agreement with the intermediacy of N-trimethylsilylpyridinium salts as a prerequisite for the occurrence of halogen exchange, neither 2-fluoropyridine and 2-fluoro-6-methylpyridine nor any 2,6-dihalopyridine reacts. Finally, bromine/chlorine and iodine/chlorine substitution can also be accomplished with 2-or 4-chloroquinoline, 1-chloroisoquinoline, 2-chloropyrimidine, chloropyrazine and 2,3-dichloroquinoxaline as substrates. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).