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4595-60-2

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4595-60-2 Usage

Chemical Properties

Off-white crystalline powder

Uses

2-Bromopyrimidine is used in the preparation of 2,7-bis(2-pyrimidyl)-9,9-dihexylfluorene by cross-coupling with 9,9-dihexylfluorene-2,7-diboronic acid. It undergoes microwave-assisted aminocarbonylation at C-2 with palladium and molybdenum hexacarbonyl.

Preparation

The recent synthesis of 2-bromopyrimidine by diazotization of 2-aminopyrimidine in hydrobromic acid has furnished a convenient starting material for other 2-substituted pyrimidines.

General Description

2-Bromopyrimidine undergoes microwave-assisited aminocarbonylation at C-2 with palladium and Mo(CO)6.

Check Digit Verification of cas no

The CAS Registry Mumber 4595-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,9 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4595-60:
(6*4)+(5*5)+(4*9)+(3*5)+(2*6)+(1*0)=112
112 % 10 = 2
So 4595-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H3BrN2/c5-4-6-2-1-3-7-4/h1-3H

4595-60-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A13791)  2-Bromopyrimidine, 98+%   

  • 4595-60-2

  • 1g

  • 92.0CNY

  • Detail
  • Alfa Aesar

  • (A13791)  2-Bromopyrimidine, 98+%   

  • 4595-60-2

  • 5g

  • 225.0CNY

  • Detail
  • Alfa Aesar

  • (A13791)  2-Bromopyrimidine, 98+%   

  • 4595-60-2

  • 25g

  • 1126.0CNY

  • Detail
  • Alfa Aesar

  • (A13791)  2-Bromopyrimidine, 98+%   

  • 4595-60-2

  • 100g

  • 4504.0CNY

  • Detail
  • Aldrich

  • (245844)  2-Bromopyrimidine  95%

  • 4595-60-2

  • 245844-1G

  • 190.71CNY

  • Detail
  • Aldrich

  • (245844)  2-Bromopyrimidine  95%

  • 4595-60-2

  • 245844-5G

  • 596.70CNY

  • Detail

4595-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromopyrimidine

1.2 Other means of identification

Product number -
Other names 2-BroMopyriMidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4595-60-2 SDS

4595-60-2Relevant articles and documents

Synthesis method of 2-bromopyrimidine

-

Paragraph 0011; 0035-0043, (2021/10/30)

The invention discloses a synthesis method of 2-bromopyrimidine, the route of which is shown as follows: the synthesis method of 2-bromopyrimidine provided by the invention comprises the following steps: carrying out oxidative addition on carbon-chlorine bonds of 2-chloropyrimidine through a metal catalyst, and then carrying out halogen exchange and reduction elimination to obtain the product 2-bromopyrimidine, and the reaction has the advantages of high operability, environment friendliness, convenience in regulation and control and the like.

Silyl-mediated halogen/halogen displacement in pyridines and other heterocycles

Schlosser, Manfred,Cottet, Fabrice

, p. 4181 - 4184 (2007/10/03)

Heating with bromotrimethylsilane converts 2-chloropyridine into 2-bromopyridine and 2-chloro-6-methylpyridine into 2-bromo-6-methylpyridine. Both 2-chloropyridines and 2-bromopyridines give the corresponding iodo compound when treated with in situ generated iodotrimethylsilane. Although 3- and 4-chloropyridine are completely inert, 2,4-dichloropyridine undergoes the halogen/halogen exchange simultaneously at the 2- and 4-position. Halogen displacement takes place exclusively at the 2-position with 2,3-dichloropyridine and 2,5-dichloropyridine. In agreement with the intermediacy of N-trimethylsilylpyridinium salts as a prerequisite for the occurrence of halogen exchange, neither 2-fluoropyridine and 2-fluoro-6-methylpyridine nor any 2,6-dihalopyridine reacts. Finally, bromine/chlorine and iodine/chlorine substitution can also be accomplished with 2-or 4-chloroquinoline, 1-chloroisoquinoline, 2-chloropyrimidine, chloropyrazine and 2,3-dichloroquinoxaline as substrates. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

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