460-08-2

Basic information

• Product Name: 2-FLUOROETHYLAMINE HYDROCHLORIDE
• Synonyms: beta-fluoroethylaminehydrochloride;2-FLUOROETHYLAMINE HYDROCHLORIDE;TIMTEC-BB SBB004369;2-FLUORETHYLAMIN HYDROCHLORID TECHN. 90%;2-FLUORETHANAMINEHYDROCHLORIDE;2-FLUORETHYLAMINEHYDROCHLORIDE;2-Fluoroethylamine hydrochloride 90%;2-FluorethylaMin hydrochloride
• CAS NO: 460-08-2
• Molecular Formula: C₂H₆FN*ClH
• Molecular Weight: 99.54
• EINECS: 207-302-3
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks
• Mol File: 460-08-2.mol

Chemical Properties

• Melting Point: 99-103 °C(lit.)
• Boiling Point: 52.1 °C at 760 mmHg
• Flash Point: 20.7 °C
• Appearance: /
• Density: 0.892g/cm³
• Vapor Pressure: 269mmHg at 25°C
• Refractive Index: 1.345
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• Sensitive: Hygroscopic
• CAS DataBase Reference: 2-FLUOROETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROETHYLAMINE HYDROCHLORIDE(460-08-2)
• EPA Substance Registry System: 2-FLUOROETHYLAMINE HYDROCHLORIDE(460-08-2)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• RTECS: KR7570000
• HazardClass: IRRITANT, HYGROSCOPIC
• Hazardous Substances Data: 460-08-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-Fluoroethylamine hydrochloride is used as a key intermediate in the synthesis of various chemical compounds, including isocyanates, ureas, and imides. Its reactivity and the presence of the fluoroethyl group make it a valuable component in the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoroethylamine hydrochloride is used as a building block for the development of new drugs and drug candidates. Its incorporation into drug molecules can impart unique properties, such as increased lipophilicity, metabolic stability, and binding affinity, which can lead to improved therapeutic efficacy and safety profiles.
Used in the Synthesis of 2-Fluoroethylisocyanate:
2-Fluoroethylamine hydrochloride is used as a starting material in the synthesis of 2-fluoroethylisocyanate, a valuable compound with potential applications in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in the Synthesis of 1,3-Bis-(2-Fluoroethyl) Urea (BFU):
2-Fluoroethylamine hydrochloride is used in the preparation of 1,3-bis-(2-fluoroethyl) urea (BFU), a compound with potential applications in various industries, including pharmaceuticals, materials science, and chemical research.
Used in the Synthesis of N-2-Fluoroethylmaleimide:
2-Fluoroethylamine hydrochloride is employed in the synthesis of N-2-fluoroethylmaleimide, a compound that can be used as a monomer in the production of polymers with unique properties, such as increased thermal stability and resistance to degradation.
Used in the Synthesis of [Cu4(O)(Ln)2(CH3COO)4] where HL= 4-Methyl-2,6-Bis(2-Fluoroethyliminomethyl) Phenol:
2-Fluoroethylamine hydrochloride is utilized in the preparation of a copper-containing complex, [Cu4(O)(Ln)2(CH3COO)4], where HL is 4-methyl-2,6-bis(2-fluoroethyliminomethyl) phenol. This complex may have potential applications in catalysis, materials science, or as a precursor to other copper-containing compounds.
Used in the Synthesis of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate (FEAnGA):
2-Fluoroethylamine hydrochloride is used in the synthesis of FEAnGA, a compound with potential applications in the development of new drugs, particularly those targeting carbohydrate metabolism or related biological processes.

InChI:InChI=1/C2H6FN/c3-1-2-4/h1-2,4H2

Upstream product

• 13880-61-0 N-<β-Fluor-ethyl>-B,B-difluor-borazan 
• 442-31-9 2-(2-fluoroethyl)isoindoline-1,3-dione 
• 894792-94-0 1-azido-2-fluoroethane 
• 371-62-0 2-fluoroethanol 

Downstream Products

• 33024-70-3 1-cyclohexyl-3-(2-fluoroethyl)thiourea 
• 13907-92-1 1,3-bis-(2-fluoroethyl) urea 
• 81420-42-0 mononitrophenyl carbonate 
• 91390-34-0 2,4,5-trichlorophenyl (2-fluoroethyl)carbamate 
• 88-75-5 2-hydroxynitrobenzene 
• 113220-16-9 ethyl 3-(2-fluoroethylamino)-2-(2,3,4, 5-tetrafluorobenzoyl) acrylate 
• 1062169-42-9 methyl 4-[6-(4-([(2-fluoroethyl)carbamoyl]amino)phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 
• 1239235-00-7 2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-6-((2-fluoroethyl)amino)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile 
• 1380330-74-4 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-[(2-fluoro-ethyl)-amide] 3-[(2-phenyl[1,2,4]triazolo[1,5-a]pyridin-7-yl)-amide] 
• 122974-04-3 N-(2-fluoroethyl)benzylamine 
• 1044256-58-7 1-(3-chloro-2-fluoro-benzyl)-3-(2-fluoro-ethyl)-urea 
• 1071448-63-9 1-(2-fluoro-ethyl)-2-phenyl-3-cyanoisourea 
• 417717-41-0 N6-(2-fluoroethyl)-4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide 
• 417716-93-9 4-(3-chloro-4-(2-fluoroethylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 

Relevant articles and documents

Preparation method of 2-fluoroethylamine hydrochloride

The invention discloses a preparation method of 2-fluoroethylamine hydrochloride. The method comprises the following steps: S1, synthesis of 2-fluoroethyl phthalimide: adding 2-fluoro-1-haloethane and phthalimide potassium into a reaction container, performing dissolving with N,N-dimethylformamide under mechanical stirring, performing reacting, carrying out reduced pressure distillation to recover N,N-dimethylformamide after the reaction is finished, adding water into the reaction container, performing heating and stirring, and performing cooling, filtering and vacuum drying to obtain a 2-fluoroethyl phthalimide intermediate; and S2, synthesis of the 2-fluoroethylamine hydrochloride: adding the 2-fluoroethyl phthalimide intermediate prepared in the step S1 into the reaction container, performing dissolving with ethanol, dropwise adding hydrazine hydrate for reaction, performing cooling after the reaction is finished, adjusting the pH to 5 with hydrochloric acid, performing refluxing for 1 hour, and performing filtering and vacuum drying to obtain white flaky crystal 2-fluoroethylamine hydrochloride. The method is simple in process, green, safe, low in cost and high in yield.

Catalytic Staudinger Reduction at Room Temperature

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

2-fluoro ethylamine hydrochloride method for the preparation of

The invention relates to a preparation method of 2-fluoroethylamine hydrochloride, which is characterized in that 2-fluoroethanol and toluene sulfochloride are reacted, hydrogen chloride gas in a reaction solution can be eliminated by conventional nitrogen, processes such as extraction can be avoided, and extraction can be prevented. According to the invention, integral reaction time is optimized, equipment utilization rate is increased, more important, through ethanol and water extraction for impurities removal, content of the obtained product is high (99%), the yield is increased, the raw material price is cheap and easily available, and no pollution is generated. Therefore, the cost is reduced, and the output of the final product is greatly increased.

GROWTH HORMONE SECRETAGOGUES

This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.