461-82-5Relevant articles and documents
Minimization of Back-Electron Transfer Enables the Elusive sp3 C?H Functionalization of Secondary Anilines
Zhao, Huaibo,Leonori, Daniele
supporting information, p. 7669 - 7674 (2021/03/08)
Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C?H functionalization.
Method for synthesizing insecticide metaflumizone intermediate p-trifluoromethoxy aniline
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Paragraph 0025-0049, (2019/01/23)
The invention discloses a method for synthesizing an insecticide metaflumizone intermediate, namely p-trifluoromethoxy aniline and belongs to the field of insecticide preparation. The method is characterized in that the p-trifluoromethoxy aniline is prepared from p-trifluoromethoxy benzene and sodium amide under the action of an auxiliary reaction mixture. The method comprises the following reaction steps: 1) in the presence of a protection gas and under an intense stirring condition, putting trifluoromethoxy benzene, the auxiliary reaction mixture and a solvent into a reaction kettle, heating to 80-95 DEG C, keeping for 2-4 hours, further adding sodium amide, heating to 135-155 DEG C, increasing the reaction pressure to 2-4 barometric pressure, and continuously reacting for 7-10 hours till completion; and 2) cooling the system, pouring into water of 5-8 times of the volume, extracting with a solvent B of 2-4 times of the volume of a reactant, washing an extraction liquid with water,drying with a drying agent, and concentrating, thereby obtaining p-trifluoromethoxy aniline. The method is simple in step, small in side reaction, high in yield, small in pollutant emission and safe to operate.
Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)
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Paragraph 0007, (2020/01/03)
The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)
