461-87-0

Basic information

• Product Name: 2-Fluoro-4-methylpyridine
• Synonyms: 2-FLUORO-4-METHYLPYRIDINE;2-FLUORO-4-PICOLINE;2-FLUORO-4-METHYLPYRIDINE 98%;2-Fluoro-4-methylpyridine/2-Fluoro-4-Picoline;2-Fluoro-4-methylpyridine97%;2-FLUORO-4-METHYLPYRIDINE, 99+%;2-FLUORO-4-PICOLINE 2-FLUORO-4-METHYLPYRIDINE;4-methyl-2-fluoropyridine
• CAS NO: 461-87-0
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.12
• EINECS: -0
• Product Categories: Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Fluoropyridines;Halopyridines;Boronic Acid;Fluorinated heterocyclic series
• Mol File: 461-87-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 160-161 °C(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.078 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.472(lit.)
• Storage Temp.: Room temperature.
• PKA: 0.24±0.10(Predicted)
• BRN: 107086
• CAS DataBase Reference: 2-Fluoro-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-methylpyridine(461-87-0)
• EPA Substance Registry System: 2-Fluoro-4-methylpyridine(461-87-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 461-87-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colourless to light yellow liquid

Uses

2-Fluoro-4-methylpyridine may be used in the preparation of:2-Fluoro-4-(iodomethyl)pyridine4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazol-2-thione2-fluoro-4-pyridinemethanol2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone2-fluoro-3-iodo-5-methylpyridine2-fluoro-4-pyridinecarboxylic acid

General Description

2-Fluoro-4-methylpyridine, also known as 2-fluoro-4-picoline, can be prepared based on Talik′s procedure from 2-amino-5-methylpyridine via diazotization. The effect of substituents on spectral properties of 2-fluoro-6-methylpyridine has been investigated based on 13C NMR, UV and IR spectral data.

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 116241-53-3 1-fluoro-4-methylpyridinium tetrafluoroborate 
• 4926-28-7 2-Bromo-4-picoline 
• 108-89-4 picoline 
• 75-05-8 acetonitrile 

Downstream Products

• 402-65-3 2-fluoropyridine-4-carboxylic acid 
• 188345-23-5 2-(2-Fluoropyridin-4-yl)-1-(3-trifluoromethylphenyl)-ethanone 
• 260981-46-2 2-methyl-2-(4-methylpyridin-2-yl)propanenitrile 
• 303162-49-4 2-(2-fluoro-pyridin-4-yl)-1-(3-methylphenyl)ethanone 
• 1104643-31-3 tert-butyl (2-fluoropyridin-4-yl)acetate 
• 365427-96-9 1-(3-chlorophenyl)-2-(2-fluoro-4-pyridyl) ethanone 
• 1176209-55-4 N-[2-[[N-ethyl-N-2-(2-fluoropyridin-4-yl)ethyl]amino]ethyl]phthalimide 
• 552331-57-4 2-fluoro-4-vinylpyridine 
• 1176209-48-5 p-nitrophenyl 2-fluoroisonicotinate 
• 80635-92-3 2-(4-methylphenyl)-4-methylpyridine 
• 1345958-08-8 1-{[2-(2-fluorophenyl)-3-oxo-2,3-dihydropyrazolo[4,3-c]quinolizin-5-yl]methyl}-4-(4-methylpyridin-2-yl)piperidine-4-carbonitrile 
• 1315463-10-5 1-methyl-6-(4-((1-(4-methylpyridin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 
• 1315611-57-4 Br^(1-)*C₁₆H₁₄F₂N₃⁽¹⁺⁾ 
• 1258750-03-6 C₆H₄N₂CH(CH₂C₆H₃F₂)C₅H₃N(CH₃)⁽¹⁺⁾*Br^(1-)=(C₆H₄N₂CH(CH₂C₆H₃F₂)C₅H₃N(CH₃))Br 

Relevant articles and documents

Rapid and efficient synthesis of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging

In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [18F]fluoronicotinamides, [ 18F]fluoroisonicotinamides and [18F]fluorobenzamides were synthesized using one-step

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.

Carboxamidation of pyridines by the system of elemental fluorine- carbonitrile-water: A useful alternative to the chichibabin amination

The title reaction with pyridine, 4-methylpyridine, 3-methylpyridine, 3- bromopyridine, nicotinonitrile, and quinoline yields 2-carboxamido derivatives regioselectively. Isoquinoline is amidated at position 1.