4672-11-1

Basic information

• Product Name: 4-PIPERIDIN-1-YL-BUTAN-1-OL
• Synonyms: AKOS BB/0086;4-PIPERIDIN-1-YL-BUTAN-1-OL;CHEMBRDG-BB 4001152;AKOS BBB/435;4-piperidin-1-ylbutan-1-ol(SALTDATA: FREE)
• CAS NO: 4672-11-1
• Molecular Formula: C₉H₁₉NO
• Molecular Weight: 157.25326
• Mol File: 4672-11-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 244.6°C at 760 mmHg
• Flash Point: 101°C
• Appearance: /
• Density: 0.949g/cm³
• Vapor Pressure: 0.00505mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: 2-8°C
• PKA: 15.17±0.10(Predicted)
• CAS DataBase Reference: 4-PIPERIDIN-1-YL-BUTAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PIPERIDIN-1-YL-BUTAN-1-OL(4672-11-1)
• EPA Substance Registry System: 4-PIPERIDIN-1-YL-BUTAN-1-OL(4672-11-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 4672-11-1(Hazardous Substances Data)

Usage

General Description

4-Piperidin-1-yl-butan-1-ol, also referred to as 1-butanol, 4-(1-piperidinyl), is a chemical compound that falls under the category of organic compounds. It is an alkyl-substituted piperidine, which is explicitly an amino compound with the general structure R2N(R')R''(R''') where R is an alkyl group. Piperidines are commonly found in many drugs, including those for depression, schizophrenia, and Parkinson's disease. The systematic name of this chemical is derived from butanol, indicating its four carbon alkyl chain, with the designation of "1-yl" signifying its connection to the nitrogen of the piperidine ring. It is utilized in various research and development applications within the pharmaceutical industry.

InChI:InChI=1/C9H19NO/c11-9-5-4-8-10-6-2-1-3-7-10/h11H,1-9H2

Upstream product

• 110-89-4 piperidine 
• 33036-62-3 4-Bromo-1-butanol 
• 5463-76-3 γ-piperidinobutyric acid hydrochloride 
• 3210-08-0 4-iodo-butan-1-ol 
• 90715-64-3 4-(1-piperidyl)butylboronic acid hydrochloride 
• 4088-34-0 1-(but-3-en-1-yl)piperidine 
• 1722-26-5 triethylamine-borane 
• 109647-01-0 formaldehyde-[bis-(4-piperidino-butyl)-acetal] 
• 6942-15-0 4-oxo-4-piperidino-butyric acid ethyl ester 
• 4753-59-7 4-Bromobutyl acetate 
• 928-51-8 4-Chloro-1-butanol 
• 96-48-0 4-butanolide 
• 90708-96-6 6-aza-1-boraspiro<5,5>undecane 

Downstream Products

• 1001380-42-2 4-fluoro-2-nitro-5-(4-piperidin-1-ylbutoxy)-phenylamine 
• 99813-47-5 1-methyl-1-[4-(3,4,5-trimethoxy-benzoyloxy)-butyl]-piperidinium; iodide 
• 102706-87-6 3,4,5-trimethoxy-trans-cinnamic acid-(4-piperidino-butyl ester) 
• 102700-31-2 1-(4-benzhydryloxy-butyl)-piperidine 
• 32066-01-6 3,4,5-trimethoxy-benzoic acid-(4-piperidino-butyl ester) 
• 102762-25-4 diphenyl-acetic acid-(4-piperidino-butyl ester); hydrochloride 

Relevant articles and documents

Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease

A series of phthalide alkyl tertiary amine derivatives were designed, synthesized and evaluated as potential multi-target agents against Alzheimer's disease (AD). The results indicated that almost all the compounds displayed significant AChE inhibitory and selective activities. Besides, most of the derivatives exhibited increased self-induced Aβ1-42 aggregation inhibitory activity compared to the lead compound DL-NBP, and some compounds also exerted good antioxidant activity. Specifically, compound I-8 showed the highest inhibitory potency toward AChE (IC50 = 2.66 nM), which was significantly better than Donepezil (IC50 = 26.4 nM). Moreover, molecular docking studies revealed that compound I-8 could bind to both the catalytic active site and peripheral anionic site of AChE. Furthermore, compound I-8 displayed excellent BBB permeability in vitro. Importantly, the step-down passive avoidance test indicated that I-8 significantly reversed scopolamine-induced memory deficit in mice. Collectively, these results suggested that I-8 might be a potent and selective AChE inhibitor for further anti-AD drug development.

Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines

Based on the definition of a 5-HT4 receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT4 receptors. The compounds were synthesized by substituting the chlorine atom of the pyrazine ring with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [3H]GR113808 (1) as the 5-HT4 receptor radioligand. The affinity values (Ki or inhibition percentages) were affected by both the substituent on the aromatic ring and the substituent on the lateral piperidine chain. A methyl group on the tricyclic ring produced a marked increase in affinity while an N-propyl or N-butyl group gave compounds with nanomolar affinities. Among the most potent ligands, 34d was selected for further pharmacological studies and evaluated in vivo. This compound acts as an antagonist/weak partial agonist in COS-7 cells stably expressing the 5-HT4(a) receptor and is of great interest as a peripheral antinociceptive agent.

Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs

Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti--inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.