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4695-13-0

4695-13-0

Identification

  • Product Name:Benzeneacetamide, a-phenyl-

  • CAS Number: 4695-13-0

  • EINECS:

  • Molecular Weight:211.263

  • Molecular Formula: C14H13 N O

  • HS Code:2924299090

  • Mol File:4695-13-0.mol

Synonyms:Acetamide,2,2-diphenyl- (6CI,7CI,8CI); 2,2-Diphenylacetamide; Diphenylacetic acid amide;NSC 29731; a,a-Diphenylacetamide

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Safety information and MSDS view more

  • Pictogram(s):R22:Harmful if swallowed.;

  • Hazard Codes:R22:Harmful if swallowed.;

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowed

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:AHH
  • Product Description:2,2-Diphenylacetamide 98%
  • Packaging:50g
  • Price:$ 298
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2,2-Diphenylacetamide
  • Packaging:1g
  • Price:$ 83
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2,2-Diphenylacetamide
  • Packaging:5g
  • Price:$ 131
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:2,2-Diphenylacetamide, 98%
  • Packaging:25g
  • Price:$ 247
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:2,2-Diphenylacetamide, 98%
  • Packaging:5g
  • Price:$ 67.2
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2,2-DIPHENYLACETAMIDE 95.00%
  • Packaging:5MG
  • Price:$ 500.36
  • Delivery:In stock
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Relevant articles and documentsAll total 30 Articles be found

-

Burton

, p. 2400 (1930)

-

-

Reid,Hunter

, p. 3515 (1948)

-

-

Rahman,Farooq

, p. 460 (1953)

-

Reactivity of molybdenum-nitride complex bearing pyridine-based PNP-type pincer ligand toward carbon-centered electrophiles

Arashiba, Kazuya,Itabashi, Takayuki,Kuriyama, Shogo,Nishibayashi, Yoshiaki

, p. 1946 - 1954 (2022/02/11)

A molybdenum-nitride complex bearing a pyridine-based PNP-type pincer ligand derived from dinitrogen is reacted with various kinds of carbon-centered electrophiles to functionalize the nitride ligand in the molybdenum complex. Methylation with MeOTf and acylation with diphenylacetyl chloride of the nitride complex afford the corresponding imide complexes via a carbon-nitrogen bond formation. In the case of reactions with phenylisocyanate and diphenylketene, the PNP ligand works as a non-innocent ligand to form the corresponding ureate and acylimide complexes, respectively. These newly synthesized complexes are characterized by X-ray analysis. As a further transformation of the prepared imide complexes, hydrolysis of the molybdenum-acylimide complex proceeds to give the corresponding amide as an organonitrogen compound together with the corresponding molybdenum-oxo complex. This result indicates that the nitrogen molecule is converted into organic amide mediated by the molybdenum-nitride complex.

Bis-Rhodamines Bridged with a Diazoketone Linker: Synthesis, Structure, and Photolysis

Belov, Vladimir N.,Bossi, Mariano L.,Hell, Stefan W.,Shojaei, Heydar

, p. 56 - 65 (2022/01/03)

Two fluorophores bound with a short photoreactive bridge are fascinating structures and remained unexplored. To investigate the synthesis and photolysis of such dyes, we linked two rhodamine dyes via a diazoketone bridge (?COCN2?) attached to p

Hydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism

Babón, Juan C.,Esteruelas, Miguel A.,López, Ana M.,O?ate, Enrique

, p. 7284 - 7296 (2021/05/29)

The hexahydride OsH6(PiPr3)2 competently catalyzes the hydration of aliphatic nitriles to amides. The main metal species under the catalytic conditions are the trihydride osmium(IV) amidate derivatives OsH3{κ2-N,O-[HNC(O)R]}(PiPr3)2, which have been isolated and fully characterized for R = iPr and tBu. The rate of hydration is proportional to the concentrations of the catalyst precursor, nitrile, and water. When these experimental findings and density functional theory calculations are combined, the mechanism of catalysis has been established. Complexes OsH3{κ2-N,O-[HNC(O)R]}(PiPr3)2 dissociate the carbonyl group of the chelate to afford κ1-N-amidate derivatives, which coordinate the nitrile. The subsequent attack of an external water molecule to both the C(sp) atom of the nitrile and the N atom of the amidate affords the amide and regenerates the κ1-N-amidate catalysts. The attack is concerted and takes place through a cyclic six-membered transition state, which involves Cnitrile···O-H···Namidate interactions. Before the attack, the free carbonyl group of the κ1-N-amidate ligand fixes the water molecule in the vicinity of the C(sp) atom of the nitrile.

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

Blacker, A. John,Chhatwal, A. Rosie,Lomax, Helen V.,Marcé, Patricia,Williams, Jonathan M. J.

, p. 5808 - 5818 (2020/06/21)

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles

Bobal, Pavel,Otevrel, Jan,Svestka, David

, p. 25029 - 25045 (2020/07/14)

We have identified a novel one-pot method for the synthesis of β-amino alcohols, which is based on C-H bond hydroxylation at the benzylic α-carbon atom with a subsequent nitrile or amide functional group reduction. This cascade process uses molecular oxygen as an oxidant and sodium bis(2-methoxyethoxy)aluminum hydride as a reductant. The substrate scope was examined on 30 entries and, although the respective products were provided in moderate yields only, the above simple protocol may serve as a direct and powerful entry to the sterically congested 1,2-amino alcohols that are difficult to prepare by other routes. The plausible mechanistic rationale for the observed results is given and the reaction was applied to a synthesis of a potentially bioactive target. This journal is

Process route upstream and downstream products

Process route

C<sub>20</sub>H<sub>16</sub>FNO
198337-87-0

C20H16FNO

benzophenone
119-61-9

benzophenone

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Diphenylacetonitrile
86-29-3

Diphenylacetonitrile

N-(diphenylmethyl)acetamide
5267-35-6

N-(diphenylmethyl)acetamide

N-(diphenylmethylene)acetamide
22800-71-1

N-(diphenylmethylene)acetamide

1-acetyl-3,3-diphenylaziridin-2-one
1375263-32-3

1-acetyl-3,3-diphenylaziridin-2-one

4-fluoroaniline
371-40-4

4-fluoroaniline

Conditions
Conditions Yield
With lithium perchlorate; In water; acetonitrile; Electrolysis;
C<sub>19</sub>H<sub>21</sub>N<sub>3</sub>O
1309976-99-5

C19H21N3O

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;
85%
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;
85%
diphenylacetic acid chloride
1871-76-7

diphenylacetic acid chloride

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With ammonia; In methanol; at 55 ℃; for 0.5h;
80%
With diethyl ether; ammonia;
With ammonia;
With ammonia;
With ammonium hydroxide;
Multistep reaction; (i) KSeCN, acetone, (ii) NH3;
With ammonium hydroxide; In dichloromethane; at 0 - 20 ℃;
Multi-step reaction with 2 steps
1: 94 percent / K2CO3 / ethyl acetate; H2O / 2 h / 0 °C
2: 1) TiCl3, 2) air / 1) H2O, EtOH, 0.5 h, 40 deg C
With titanium(III) chloride; air; potassium carbonate; In water; ethyl acetate;
With ammonia; In water; at 25 ℃; for 0.5h;
0.78 g
Diphenylacetonitrile
86-29-3

Diphenylacetonitrile

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With sodium hydroxide; poly(ethylene glycol)-400; for 0.025h; microwave irradiation;
94%
With tetra(n-butyl)ammonium hydroxide; In ethanol; water; at 80 ℃; for 12h; chemoselective reaction; Green chemistry;
92%
With Os(hydride)6(triisopropylphosphine)2; water; In tetrahydrofuran-d8; at 100 ℃; for 4h; Inert atmosphere;
79%
With C34H38N6NiO2(2+)*2Cl(1-); water; In isopropyl alcohol; at 70 ℃; for 12h; Schlenk technique; Inert atmosphere;
37%
With sodium hydroxide; ethanol; dihydrogen peroxide;
With potassium hydroxide; ethanol;
With boron trifluoride; water; acetic acid; anschliessend mit wss. NaOH behandeln;
With sodium hydroxide; dihydrogen peroxide; dimethyl sulfoxide; In methanol; water; at 50 ℃; for 1h;
With potassium hydroxide; water; In ethanol; for 12h; Reflux;
With sulfuric acid; at 20 ℃; for 24h;
With [Os(η6-p-cymene)(OH)(1,3-bis(2,6-diisopropylphenyl)imidazolylidene)](CF3SO3); water; isopropyl alcohol; potassium hydroxide; In para-xylene; at 120 ℃; for 9h; Schlenk technique; Inert atmosphere;
91 %Chromat.
Diphenylacetonitrile; With dimethyl sulfoxide; sodium hydroxide; In ethanol; water; at 55 ℃; for 0.133333h; Flow reactor;
With dihydrogen peroxide; In ethanol; water; at 55 ℃; Flow reactor;
75 %Chromat.
1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one
182318-00-9

1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With ammonium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;
90%
1,1-Diphenylethylene
530-48-3

1,1-Diphenylethylene

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With pyridine; ammonium hydroxide; sulfur; at 230 ℃;
Multi-step reaction with 3 steps
1: glacial acetic acid; concentrated nitric acid
2: hydrochloride of tin dichloride; alcohol
3: KOH; alcohol
With potassium hydroxide; ethanol; hydrochloride of tin dichloride; nitric acid; acetic acid;
2-diphenylmethyleneoxazolidine-4,5-dione
97320-51-9

2-diphenylmethyleneoxazolidine-4,5-dione

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
With phosphorous acid trimethyl ester; In benzene; for 8h; Heating;
80%
methyl 2,2-diphenylacetate
3469-00-9

methyl 2,2-diphenylacetate

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: sodium hydroxide / ethanol / 6 h / 85 °C
2: thionyl chloride / toluene / 0.5 h / 55 °C / 750.08 Torr
3: ammonia / methanol / 0.5 h / 55 °C
With thionyl chloride; ammonia; sodium hydroxide; In methanol; ethanol; toluene;
Methyl phenyldiazoacetate
22979-35-7

Methyl phenyldiazoacetate

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: SW-I (HClO4 surface modified sewage sludge) / 1,2-dichloro-ethane / 7 h / 20 - 70 °C / 750.08 Torr / Green chemistry
2: sodium hydroxide / ethanol / 6 h / 85 °C
3: thionyl chloride / toluene / 0.5 h / 55 °C / 750.08 Torr
4: ammonia / methanol / 0.5 h / 55 °C
With thionyl chloride; ammonia; sodium hydroxide; In methanol; ethanol; 1,2-dichloro-ethane; toluene;
benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

2,2-diphenylacetamide
4695-13-0

2,2-diphenylacetamide

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 40 °C / Microwave irradiation
2: SW-I (HClO4 surface modified sewage sludge) / 1,2-dichloro-ethane / 7 h / 20 - 70 °C / 750.08 Torr / Green chemistry
3: sodium hydroxide / ethanol / 6 h / 85 °C
4: thionyl chloride / toluene / 0.5 h / 55 °C / 750.08 Torr
5: ammonia / methanol / 0.5 h / 55 °C
With thionyl chloride; 4-toluenesulfonyl azide; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In methanol; ethanol; 1,2-dichloro-ethane; toluene; acetonitrile;

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