470-05-3

Basic information

• Product Name: diosgenin
• CAS NO: 470-05-3
• Molecular Weight: 414.629
• Mol File: 470-05-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diosgenin(CAS DataBase Reference)
• NIST Chemistry Reference: diosgenin(470-05-3)
• EPA Substance Registry System: diosgenin(470-05-3)

Safety Data

• Hazardous Substances Data: 470-05-3(Hazardous Substances Data)

Upstream product

• 94805-85-3 melongoside F 
• 89203-43-0 melongoside H 
• 91574-93-5 afromontoside 
• 65604-83-3 C₅₂H₈₆O₁₆ 
• 65604-80-0 mixture of 3-O-<α-L-rhamnopyranosyl-(1->2)><β-D-xylopyranosyl(1->3)>-β-D-glucopyranosides of diosgenin and yamogenin 
• 54522-52-0 26-O-β-D-glucopyranosyl-22-O-methylfurost-5-ene-3β,26-diol 3-O-β-chacotrioside 
• 6808-14-6 pseudodiosgenin 

Downstream Products

• 6808-14-6 pseudodiosgenin 
• 1061-54-7 Diosgenin monoacetate 
• 1061-54-7 yamogenin-acetate 
• 1061-54-7 diosgenin acetate 
• 2137-22-6 (20S,22S,25R)-spirosol-1,4-dien-3-one 
• 6870-79-7 (25R)-spirost-4-ene-3-one 
• 105078-98-6 (25S)-3β-acetoxy-26-trityloxycholest-5-ene 
• 113917-72-9 (25S)-3-acetoxy-26-tosyloxycholest-5-ene 
• 96481-07-1 (25S)-3β,26-dihydroxycholest-5-en-16-one 
• 113917-68-3 C₄₇H₆₀F₆O₆ 
• 113917-68-3 C₄₇H₆₀F₆O₆ 
• 113917-67-2 (25S)-3,26-bis-p-nitrobenzoylcholest-5-en-16-one 
• 113917-66-1 (25S)-3β,26-bis-p-nitrobenzoyloxycholest-5-en-16β-ol 
• 13095-61-9 (25R)-cholest-5-ene-3β,26-diol 

Relevant articles and documents

Spirostanols obtained by cyclization of pseudosaponin derivatives and comparison of anti-platelet agglutination activities of spirostanol glycosides

Naturally occurring saponins 3 and 4 have a normal type F ring and α- arranged CH3-21 group. Treatments of pseudosaponin peracetates 18 and 19 derived from 3 and 4, respectively, with alcoholic KOH, followed by acidification with acetic acid, gave spirostanols 20 and 22 having iso type F rings as major products. Structural analyses of sapogenins and saponins derived from pseudo derivatives 11, 12, 18 and 19 were performed by comparisons of their 1H-NMR spectral data and the X-ray analytical data of 3-O-p-bromobenzoyl sarsasapogenin 7, 3-O-acetyl diosgenin 13 and saponin 20. The mechanisms of ring-closure reaction of the side chain at C-22 of pseudosapogenins and pseudosaponins were deduced using stereomodels of the spirostanols derived from 11 under various reaction conditions. Inhibitory activities of saponin diglycosides 3, 4, 20, 21 and 25 on human platelet agglutinations induced by ADP and ristocetin were compared. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Afromontoside. A New Cytotoxic Principle from Dracaena afromontana

A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana.It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L-rhamnopyranoside 3-O-(4)>-β-D-glucopyranoside) by spectral and chemical methods.The aglycone of afromotoside, diosgenin, as well as dihydrodiosgenin and severall structurally related compounds have been shown to be cytotoxic to cultured KB cells.