4705-43-5

Basic information

• Product Name: 4-(1-Piperidinyl)-2-butenoic acid
• Synonyms: 1-Piperidinecrotonic acid;4-(1-Piperidinyl)-2-butenoic acid;E)-4-piperidin-1-ylbut-2-enoic acid;2-Butenoic acid,4-(1-piperidinyl)-
• CAS NO: 4705-43-5
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.2209
• Mol File: 4705-43-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 319.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.082±0.06 g/cm3(Predicted)
• PKA: 4.00±0.10(Predicted)
• CAS DataBase Reference: 4-(1-Piperidinyl)-2-butenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-Piperidinyl)-2-butenoic acid(4705-43-5)
• EPA Substance Registry System: 4-(1-Piperidinyl)-2-butenoic acid(4705-43-5)

Safety Data

• Hazardous Substances Data: 4705-43-5(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 23114-90-1 (E)-4-(piperidin-1-yl)butan-2-enoic ethyl ester 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 

Downstream Products

• 1110813-31-4 Dacomitinib 

Relevant articles and documents

QUINAZOLINE DERIVATIVE AND USE THEREOF

The present invention relates to a series of quinazoline compounds, especially compounds as represented by formula (I), isomers thereof or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use thereof as Pan-HER tyrosine kinase inhibitors.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.