4730-54-5Relevant articles and documents
Phosphoric triamides. 31Phosphorus NMR chemical shift as a function of the P-N bond characteristics
Bourne, Susan A.,Mbianda, Xavier Y.,Modro, Tomasz A.,Nassimbeni, Luigi R.,Wan, Huijie
, p. 83 - 88 (1998)
Six phosphoric triamides in which amide nitrogens are incorporated into an increasing number (from 0 to 3) of the 1,3,2-diazaphospholidin-2-one rings have been prepared and their crystal structures have been determined. The structural changes from the non-cyclic to the mono-, di- and tri-cyclic systems result in the decrease of the N-P-N bond angles and the increase of the P-N bond distance. These changes are paralleled by a strong deshielding of the 31P nucleus, leading to an exceptionally high δp value for the tricyclic derivative. The δp-structural parameters relationship is discussed in terms of the changes in hybridization of phosphorus and the variation in the P-N bond order.
Measurement of the rate of copper(II) exchange for 64Cu complexes of bifunctional chelators
Maheshwari, Vidhi,Dearling, Jason L.J.,Treves, S. Ted,Packard, Alan B.
, p. 318 - 323 (2012)
Measurement of the rate of loss of 64Cu from the chelators used in the preparation of 64Cu-labeled proteins is critical to the development of effective 64Cu-labeled radiopharmaceuticals. Typically, however, this assessment has been made indirectly, by comparison of the relative uptake of the labeled proteins in the liver, or under non-physiological conditions such as hot 5 M HCl. In the present study, we measured the rate of loss of 64Cu from a series of chelators (DOTA, TETA, and NOTA) that are commonly used to label proteins as a function of [Cu2+] (1, 2, and 5 μM) and pH (7.5, 6.0. and 5.0). We found that 64Cu-NOTA is somewhat more kinetically stable than 64Cu-TETA and that both 64Cu-NOTA and 64Cu-TETA are much more kinetically stable than 64Cu-DOTA. Furthermore, the rate of loss of 64Cu from Cu-DOTA increased with higher [Cu 2+] and pH while the rate of loss of 64Cu from Cu-TETA and Cu-NOTA was minimally dependent on [Cu2+] and pH. These results suggest that NOTA is preferable to TETA and DOTA for the preparation of 64Cu-labeled proteins.
DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
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Paragraph 0048; 0056-0057, (2021/03/19)
To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where X is H or a substituted carbamoyl group, R1, R2, R3, and R4 independently represent H or a C1-8 linear or branched alkyl group).SELECTED DRAWING: None
An Efficient Synthesis of N,N,N-Substituted 1,4,7-Triazacyclononane
Huang, Yong,Liu, Yajing,Liu, Song,Wu, Renbo,Wu, Zehui
, p. 1546 - 1551 (2018/04/20)
A new and efficient synthetic approach is reported for various N,N,N-substituted 1,4,7-triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7-tribenzyl-1,4,7-triazonane-2,6-dione reduction with LiAlH4, removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N,N,N-substituted TACN derivatives.