473732-59-1

Basic information

• Product Name: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE
• Synonyms: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE;1-[3-(Trifluoromethyl)phenyl]propylamine;α-Ethyl-3-(trifluoromethyl)-benzenemethanamine
• CAS NO: 473732-59-1
• Molecular Formula: C₁₀H₁₂F₃N
• Molecular Weight: 203.2
• Mol File: 473732-59-1.mol

Chemical Properties

• Boiling Point: 205.5°C at 760 mmHg
• Flash Point: 83.8°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.249mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(473732-59-1)
• EPA Substance Registry System: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(473732-59-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 473732-59-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved efficacy and selectivity. Its unique chemical properties allow for the creation of diverse drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Research and Development:
(RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE serves as a valuable compound in the research and development of new chemicals. Its unique structure and properties make it an ideal candidate for exploring novel chemical reactions and syntheses, leading to the discovery of innovative chemical entities with potential applications across various industries.
Used in Organic Synthesis:
As a building block in organic synthesis, (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE is used for the creation of various derivatives and analogs. Its versatility allows chemists to modify its structure to develop new compounds with tailored properties, opening up possibilities for applications in various fields, including materials science, medicinal chemistry, and specialty chemicals.

InChI:InChI=1/C10H12F3N/c1-2-9(14)7-4-3-5-8(6-7)10(11,12)13/h3-6,9H,2,14H2,1H3

Upstream product

• 618-97-3 1-<3-(trifluoromethyl)phenyl>propan-1-ol 
• 1533-03-5 3-(trifluoromethyl)propiophenone 

Downstream Products

• 1255915-23-1 4-(3,4-dioxo-2-(1-(3-(trifluoromethyl)phenyl)propylamino)cyclobut-1-enylamino)-3-hydroxy-N,N-dimethylpicolinamide 

Relevant articles and documents

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.