4747-46-0

Basic information

• Product Name: 1-phenyl-1H-pyrazole-3-carboxylic acid
• Synonyms: 1-phenyl-1H-pyrazole-3-carboxylic acid;1-PHENYL-3-PYRAZOLECARBOXYLIC ACID;1-phenylpyrazole-3-carboxylic acid
• CAS NO: 4747-46-0
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• Mol File: 4747-46-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 266 °C(Solv: water (7732-18-5))
• Boiling Point: 379.635°C at 760 mmHg
• Flash Point: 183.397°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• PKA: 3.92±0.10(Predicted)
• CAS DataBase Reference: 1-phenyl-1H-pyrazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1H-pyrazole-3-carboxylic acid(4747-46-0)
• EPA Substance Registry System: 1-phenyl-1H-pyrazole-3-carboxylic acid(4747-46-0)

Safety Data

• Hazardous Substances Data: 4747-46-0(Hazardous Substances Data)

Usage

General Description

1-phenyl-1H-pyrazole-3-carboxylic acid is a chemical compound with the molecular formula C10H8N2O2. It is a derivative of pyrazole and contains a phenyl group attached to the first carbon of the pyrazole ring. 1-phenyl-1H-pyrazole-3-carboxylic acid is used in organic synthesis and pharmaceutical research due to its potential biological activity and medicinal properties. It has been investigated for its potential as an inhibitor of enzyme activity and as a ligand for metal complexes. 1-phenyl-1H-pyrazole-3-carboxylic acid may also have applications in the development of new drugs for the treatment of various conditions.

InChI:InChI=1/C10H8N2O2/c13-10(14)9-6-7-12(11-9)8-4-2-1-3-5-8/h1-7H,(H,13,14)

Upstream product

• 1128-54-7 3-methyl-1-phenyl-1H-pyrazole 
• 7188-95-6 methyl 1-phenyl-1H-pyrazole-3-carboxylate 
• 107518-40-1 1-phenyl-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester 
• 23429-68-7 1,1'-diphenyl-4,5,4',5'-tetrahydro-1H,1'H-[3,3']bipyrazolyl 
• 508191-77-3 3-phenylsydnone 
• 18093-85-1 1-phenyl-3-cyanopyrazole 
• 98-80-6 phenylboronic acid 
• 936-53-8 1-phenyl-4,5-dihydro-1H-pyrazole 
• 875440-31-6 2,2'-diphenyl-2H,2'H-5,5'-ethanediyl-bis-pyrazole-3-carboxylic acid diethyl ester 
• 100-63-0 phenylhydrazine 
• 89-25-8 edaravone 
• 83959-41-5 1-phenyl-3-trichloromethyl-1H-pyrazole 

Downstream Products

• 7188-95-6 methyl 1-phenyl-1H-pyrazole-3-carboxylate 
• 423768-37-0 1-phenyl-1H-pyrazole-5-carbonyl chloride 
• 509077-92-3 1-phenyl-1H-pyrazole-3-carboxylic acid hydrazide 
• 1128-56-9 3-amino-1-phenylpyrazole 
• 2753-56-2 N-(1-phenyl-1H-pyrazol-3-yl)-acetamide 
• 458561-89-2 1-phenyl-1H-pyrazole-3-carbonyl azide 
• 458565-94-1 (1-phenyl-1H-pyrazol-3-yl)-carbamic acid ethyl ester 

Relevant articles and documents

Photo-induced deep aerobic oxidation of alkyl aromatics

Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].

PYRAZOLE DERIVATIVES AS S1P1 AGONISTS

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by sphingosine-1-phosphate receptors (S1P1) agonists.