474709-76-7

Basic information

• Product Name: (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID
• Synonyms: AKOS BRN-0805;4-ETHOXYCARBONYL-3-CHLOROPHENYLBORONIC ACID;(3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID;3-CHLORO-4-(ETHOXYCARBONYL)PHENYLBORONIC ACID;ETHYL 4-BORONO-2-CHLOROBENZOATE;3-Chloro-4-(ethoxycarbonyl)benzeneboronic acid, pinacol ester;3-Chloro-4-(ethoxycarbonyl)benzeneboronic acid, pinacol ester 96%;4-Ethoxycarbonyl-3-chlorophenylboronic acid,pinacol ester
• CAS NO: 474709-76-7
• Molecular Formula: C₁₅H₂₀BClO₄
• Molecular Weight: 310.58
• Mol File: 474709-76-7.mol

Chemical Properties

• Boiling Point: 401.335 °C at 760 mmHg
• Flash Point: 196.521 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID(474709-76-7)
• EPA Substance Registry System: (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID(474709-76-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 474709-76-7(Hazardous Substances Data)

Usage

Uses

4-Ethoxycarbonyl-3-chlorophenylboronic acid, pinacol ester

InChI:InChI=1/C15H20BClO4/c1-6-19-13(18)11-8-7-10(9-12(11)17)16-20-14(2,3)15(4,5)21-16/h7-9H,6H2,1-5H3

Upstream product

• 76008-74-7 Ethyl 4-bromo-2-chlorobenzoate 
• 7335-25-3 ethyl 2-chlorobenzoate 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.