476168-17-9

Basic information

• Product Name: METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID
• Synonyms: METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID;Benzoic acid,2-aMino-4,5-bis(2-Methoxyethoxy)-, Methyl ester;Methyl 2-amino-4,5-di(2-methoxyethoxy)benzoate
• CAS NO: 476168-17-9
• Molecular Formula: C₁₄H₂₁NO₆
• Molecular Weight: 299.321
• Mol File: 476168-17-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• PKA: 2.51±0.10(Predicted)
• CAS DataBase Reference: METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID(476168-17-9)
• EPA Substance Registry System: METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID(476168-17-9)

Safety Data

• Hazardous Substances Data: 476168-17-9(Hazardous Substances Data)

Usage

General Description

Methyl Ester, 2-Amino-4,5-Bis(2-Methoxyethoxy)benzoic Acid is a chemical compound that is commonly used as an intermediate in organic synthesis. It is a derivative of benzoic acid and contains an amino group and two methoxyethoxy groups attached to the benzene ring. METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID is often used in the production of pharmaceuticals, agrochemicals, and dyes, as well as in the formulation of coatings and adhesives. It has potential applications in the fields of medicine and material science due to its unique chemical structure and properties.

Upstream product

• 80407-64-3 3,4-bis(2-methoxyethoxy)benzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 121-33-5 vanillin 
• 819813-71-3 3,4-bis(2-methoxyethoxy)-benzoic acid 
• 179688-14-3 methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 501684-22-6 methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 
• 3943-89-3 Ethyl protocatechuate 

Downstream Products

• 882511-67-3 4-(4-iodo-phenoxy)-6,7-bis-(2-methoxy-ethoxy)-quinazoline 
• 882511-66-2 4-(3-iodo-phenoxy)-6,7-bis-(2-methoxy-ethoxy)-quinazoline 
• 882511-64-0 [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-iodo-phenyl)-amine 
• 882511-65-1 [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine 
• 882511-71-9 (3-{4-[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yloxy]-phenyl}-prop-2-ynyl)-dicyclohexyl-amine 
• 882511-70-8 (3-{3-[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yloxy]-phenyl}-prop-2-ynyl)-dicyclohexyl-amine 
• 882511-69-5 [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[4-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine 
• 882511-68-4 [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 
• 179688-29-0 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one 
• 183319-69-9 erlotinib hydrochloride 
• 179688-29-0 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone 

Relevant articles and documents

Preparation method of erlotinib intermediate

The invention relates to a preparation method of an erlotinib intermediate. The method concretely comprises the following steps: 1, dissolving vanillin in an organic solvent I, adding aluminum trichloride, adding pyridine in a dropwise manner, and reacting to obtain ELTA; 2, dissolving the ELTA in an organic solvent II, adding 2-chloroethylmethyl ether, potassium carbonate and a phase transfer catalyst, and reacting to obtain ELTB; 3, adding the ELTB to water, adding an alkali and potassium permanganate, and reacting to obtain ELTC; 4, adding concentrated sulfuric acid to methanol in a dropwise manner, adding the ELTC to the above reaction system, and reacting to obtain ELTD; 5, adding concentrated sulfuric acid to concentrated nitric acid in a dropwise manner, dissolving the ELTD in an organic solvent IV, adding a prepared mixed acid to the reaction system, and reacting to obtain ELTE; 6, adding the ELTE, iron powder and ammonium chloride to an organic solvent V, adding concentrated hydrochloric acid in a dropwise manner, and reacting to obtain ELTF; and 7, adding the ELTF, trimethyl orthoformate and ammonium acetate to an organic solvent VI, and reacting to obtain the erlotinib intermediate.

Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline

A method of synthesizing 6,7-substituted 4-anilino quinazoline employs 3,4-substituted benzoic acid as an initial reactant, and the 6,7-substituted 4-anilino quinazoline is obtained by an esterifying step, a nitrating step, a reducing step, a cyclizing step, and an one-pot reaction. In the above method, the initial reactant has low cost and yield. of the 6,7-substituted 4-anilino quinazoline is high, therefore, production cost can be reduced effectively, and competitive power of the product of the 6,7-substituted 4-anilino quinazoline can be improved.

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

The syntheses and biological evaluations of 4-anilinoquinoline-3-carbonitrile analogues of the three clinical lead 4-anilinoquinazolines Iressa, Tarceva, and CI-1033 are described. The EGFR and HER-2 kinase inhibitory activities and the cell growth inhibition of the two series are compared with each other and with the clinical lead EKB-569. Similar activities are observed between these two series.