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Cas Database

4774-14-5

4774-14-5

Identification

  • Product Name:2,6-Dichloropyrazine

  • CAS Number: 4774-14-5

  • EINECS:225-316-8

  • Molecular Weight:148.979

  • Molecular Formula: C4H2Cl2N2

  • HS Code:29339990

  • Mol File:4774-14-5.mol

Synonyms:Pyrazine, 2,6-dichloro-;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn, IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2,6-Dichloropyrazine
  • Packaging:100g
  • Price:$ 80
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2,6-Dichloropyrazine >99.0%(GC)
  • Packaging:5g
  • Price:$ 29
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2,6-Dichloropyrazine >99.0%(GC)
  • Packaging:25g
  • Price:$ 86
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2,6-Dichloropyrazine 98%
  • Packaging:5g
  • Price:$ 113
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2,6-Dichloropyrazine 98%
  • Packaging:25g
  • Price:$ 339
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2,6-Dichloropyrazine 98%
  • Packaging:1g
  • Price:$ 43
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:2,6-Dichloropyrazine
  • Packaging:5g
  • Price:$ 10
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:2,6-Dichloropyrazine
  • Packaging:1g
  • Price:$ 9
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:2,6-Dichloropyrazine
  • Packaging:25g
  • Price:$ 13
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:2,6-Dichloropyrazine
  • Packaging:100g
  • Price:$ 39
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

Preparation method of 2, 6-dichloropyrazine

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Paragraph 0034; 0040; 0053-0061, (2020/04/22)

The invention discloses a preparation method of 2, 6-dichloropyrazine. The method comprises the following steps: taking glycine and glyoxal as raw materials, carrying out ammoniation and cyclization reactions to prepare 2-hydroxypyrazine sodium; and reacting 2-hydroxypyrazine sodium with thionyl chloride under the catalytic action of N,N-diisopropylethylamine to prepare 2-chloropyrazine; wherein pyridine is used as a solvent, and 2-chloropyrazine is subjected to chlorination of chlorine to obtain 2,6-dichloropyrazine. The method has the advantages that the raw material namely glycine is cheapand easily available, and phosphorus oxychloride is not used as a chlorination reagent, so that the generation of organic phosphorus-containing wastewater is greatly reduced, and an effective way is provided for efficient green industrial production of 2, 6-dichloropyrazine.

Novel pyrazines from the myxobacterium Chondromyces crocatus and marine bacteria

Dickschat, Jeroen S.,Reichenbach, Hans,Wagner-Doebler, Irene,Schulz, Stefan

, p. 4141 - 4153 (2007/10/03)

The volatiles released by two strains of the myxobacterium Chondromyces crocatus and seven strains of marine Alpha-proteobacteria from the North Sea were collected using the CLSA or SPME headspace methods and analysed by GC-MS. In the extracts of C. crocatus 27 pyrazines were identified, belonging to different classes. 2,5-Dialkylpyrazines and related 3-methoxy-2,5- dialkylpyrazines dominated. Several pyrazines like 2-(1-methylethenyl)-5-(1- methylethyl)-pyrazine (7) and 3-methoxy-2,5-dialkylpyrazines with methyl, isopropyl, isobutyl or sec-butyl side-chains were obtained from natural sources for the first time. It was essential for the identification to rely on synthetic reference materials, which were obtained using Fuerstner's iron-catalysed coupling of chloropyrazines with Grignard reagents or condensation of azido ketones as key steps. The synthetic material allowed the identification of two previously unknown attractants of bacterial origin for the pineapple beetle Carpophilus humeralis, namely 3-methoxy-2-(1-methylpropyl)-5-(2-methylpropyl) pyrazine (17) and 3-methoxy-2,5-bis(1-methylpropyl)pyrazine (52). Several 2,5-dialkylpyrazines were identified in the extracts of the marine Alphaproteobacteria. The unique 2,5-dimethyl-3-(methylsulfanyl)pyrazine (67) represents a new type of natural pyrazine. Our results, together with literature reports, show that pyrazines are an important class of bacterial volatiles which might be more widespread than previously thought. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Studies on Pyrazines. 29. High Regioselective Synthesis of Chloropyrazines from 3-Substituted Pyrazine 1-Oxides

Sato, Nobuhiro,Fujii, Megumi

, p. 1177 - 1180 (2007/10/02)

Reaction of 3-methoxy- or 3-chloropyrazine 1-oxides with refluxing phosphoryl chloride in the presence of amine led to a high regioselective formation of 3-substituted 2-chloropyrazines.In contrast, the use of chloroacetyl chloride instead of phosphoryl chloride enabled different regioselectivity to yield 6-substituted 2-chloropyrazines, particularly 3-methoxycarbonylpyrazine 1-oxide was almost exclusively converted into methyl 6-chloropyrazinecarboxylate under conditions without the amine.

Studies on Pyrazines. Part 10. Substitution Effect on Reaction of Pyrazine N-Oxides with Phosphoryl chloride

Sato, Nobuhiro

, p. 2860 - 2875 (2007/10/02)

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Process route upstream and downstream products

Process route

3-chloropyrazine 1-oxide
6863-76-9

3-chloropyrazine 1-oxide

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With trichlorophosphate; for 2h; Yield given. Yields of byproduct given; Heating;
With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; for 2h; Yield given. Yields of byproduct given; Heating;
3-chloropyrazine 1-oxide
6863-76-9

3-chloropyrazine 1-oxide

2-chloropyrazin
14508-49-7

2-chloropyrazin

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With trichlorophosphate; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
1,4-pyrazine
290-37-9

1,4-pyrazine

water
7732-18-5

water

chlorine
7782-50-5

chlorine

2-chloropyrazin
14508-49-7

2-chloropyrazin

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
at 350 ℃; Product distribution;
2-chloropyrazin
14508-49-7

2-chloropyrazin

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With pyridine; chlorine; at 110 ℃; for 2h; Reagent/catalyst;
87.3%
With sulfuryl dichloride; at 120 ℃;
Pyrazin-N<sub>.</sub>N'-dioxyd
2423-84-9

Pyrazin-N.N'-dioxyd

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With trichlorophosphate; for 6h; Heating;
84%
1,4-pyrazine
290-37-9

1,4-pyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With water; chlorine; at 400 - 500 ℃;
With water; chlorine; at 400 - 500 ℃;
2-chloropyrazin
14508-49-7

2-chloropyrazin

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With chlorine; at 475 ℃;
1,4-pyrazine
290-37-9

1,4-pyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With water; chlorine; at 350 ℃;
Pyrazin-N<sub>.</sub>N'-dioxyd
2423-84-9

Pyrazin-N.N'-dioxyd

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With trichlorophosphate; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
2-chloropyrazin
14508-49-7

2-chloropyrazin

chlorine
7782-50-5

chlorine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
at 120 ℃;

Global suppliers and manufacturers

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  • Simagchem Corporation
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  • Chemwill Asia Co., Ltd.
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  • Amadis Chemical Co., Ltd.
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  • Emails:sales@amadischem.com
  • Main Products:29
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Shanghai Upbio Tech Co.,Ltd
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  • Afine Chemicals Limited
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