4775-98-8

Basic information

• Product Name: 6-methylpiperidin-2-one
• Synonyms: 6-methylpiperidin-2-one;6-Methyl-2-Piperidinone;2-Piperidinone, 6-methyl-;2-PIPERIDONE, 6-METHYL-;Hexanoic acid, 5-amino-, lactam;Methylpentanone isoxime;Methylpentanonisoxim [German]
• CAS NO: 4775-98-8
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.15764
• EINECS: 225-321-5
• Mol File: 4775-98-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 87.2-88 °C
• Boiling Point: 254°Cat760mmHg
• Flash Point: 138.6°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: 1.438
• Storage Temp.: 2-8°C
• PKA: 16.67±0.40(Predicted)
• CAS DataBase Reference: 6-methylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methylpiperidin-2-one(4775-98-8)
• EPA Substance Registry System: 6-methylpiperidin-2-one(4775-98-8)

Safety Data

• Hazardous Substances Data: 4775-98-8(Hazardous Substances Data)

Usage

General Description

6-methylpiperidin-2-one is a chemical compound that belongs to the class of piperidone derivatives. It is an organic compound with the molecular formula C6H11NO and a molecular weight of 113.16 g/mol. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the production of fragrances and flavorings. 6-methylpiperidin-2-one is a colorless to pale yellow liquid with a distinct odor, and it is considered to be a stable compound under normal conditions.

InChI:InChI=1/C6H11NO/c1-5-3-2-4-6(8)7-5/h5H,2-4H2,1H3,(H,7,8)

Upstream product

• 1120-72-5 2-Methylcyclopentanone 
• 10412-98-3 5-oxohexanenitrile 
• 3128-06-1 5-ketohexanoic acid 
• 77287-34-4 formamide 
• 31685-30-0 1-methyl-but-3-enylamine 
• 201230-82-2 carbon monoxide 
• 13984-50-4 methyl levulinate 
• 1121-89-7 piperidine-2,6-dione 
• 917-64-6 methyl magnesium iodide 
• 75-16-1 methylmagnesium bromide 
• 72374-48-2 6-Hydroxy-6-methyl-3,4,5,6-tetrahydro-2(1H)-pyridone 
• 100-64-1 cyclohexanone-oxime 
• 92041-66-2 6-benzoylamino-5-methylpentanoic acid 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 

Downstream Products

• 3279-76-3 6-hydroxy-2-methylpyridine 
• 128957-77-7 2-methyl-6-oxopiperidine-1-carboxylic acid benzyl ester 
• 423157-43-1 6-methyl-1-(4-nitrobenzoyl)-2-piperidinone 
• 28720-60-7 solenopsin A 
• 63950-16-3 cis-6-methyl-2-undecanylpiperidine 
• 109-05-7 2-Methylpiperidin 
• 2098457-92-0 apixaban 
• 2098457-93-1 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-6-methyl-1-piperidinyl)phenyl]-2(1H)-pyridone 
• 1352448-53-3 6-methyl-1-(4-nitrophenyl)piperidin-2-one 
• 1352448-58-8 1-(3-methoxy-4-nitrophenyl)-6-methylpiperidin-2-one 
• 1352448-57-7 2-methoxy-4-(2-methyl-6-oxopiperidin-1-yl)benzaldehyde 
• 1352448-56-6 methyl 2-methoxy-4-(2-methyl-6-oxopiperidin-1-yl)benzoate 
• 1352448-52-2 methyl 4-(2-methyl-6-oxopiperidin-1-yl)benzoate 
• 1352448-55-5 6-methyl-1-(4-(trifluoromethyl)phenyl)piperidin-2-one 

Relevant articles and documents

Production of Piperidine and δ-Lactam Chemicals from Biomass-Derived Triacetic Acid Lactone

Piperidine and δ-Lactam chemicals have wide application, which are currently produced from fossil resource in industry. Production of this kind of chemicals from lignocellulosic biomass is of great importance, but is challenging and the reported routes gi

Method for synthesizing lactam derivative without catalyst

The invention discloses a simple synthesis method for a lactam derivative. The method comprises the step that with formamide as an amine source and a hydrogen donor (hydrolyzed to produce formic acid)and keto acid as raw materials, the lactam derivative is easily synthesized through a cycloamination reaction without a solvent or a catalyst. Compared with previous reports, the time required for the reaction is greatly shortened, the selectivity is remarkably improved, the conversion rate of the keto acid derivative is 99%, and the yield of the lactam derivative can reach 70-94%.

Benzimidazole derivatives, preparation methods and uses theirof

The present invention relates to benzimidazole compounds useful in treating for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention of one or more symptoms of cancer, transplant rejections. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK4 and/or CDK6, using the compounds provided herein.