4785-07-3

Basic information

• Product Name: guanylyl-(3'-5')-uridine
• Synonyms: guanylyl-(3'-5')-uridine;3'-O-(5'-Uridyl)guanosine
• CAS NO: 4785-07-3
• Molecular Formula: C₁₉H₂₄N₇O₁₃P
• Molecular Weight: 589.409
• Mol File: 4785-07-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.31g/cm³
• CAS DataBase Reference: guanylyl-(3'-5')-uridine(CAS DataBase Reference)
• NIST Chemistry Reference: guanylyl-(3'-5')-uridine(4785-07-3)
• EPA Substance Registry System: guanylyl-(3'-5')-uridine(4785-07-3)

Safety Data

• Hazardous Substances Data: 4785-07-3(Hazardous Substances Data)

Usage

General Description

Guanylyl-(3'-5')-uridine is a chemical compound with a structure that consists of a guanine nucleotide linked to a uridine nucleotide through a phosphodiester bond. guanylyl-(3'-5')-uridine plays a significant role in several biological processes, including mRNA capping and mRNA degradation. In mRNA capping, guanylyl-(3'-5')-uridine is added to the 5' end of newly synthesized mRNA molecules to protect them from degradation and facilitate their translation. Additionally, it is involved in the regulation of gene expression and control of cellular functions. Furthermore, guanylyl-(3'-5')-uridine has been studied for its potential therapeutic applications in anti-cancer and anti-viral treatments due to its involvement in regulating cell growth and viral replication. Overall, the chemical properties and biological functions of guanylyl-(3'-5')-uridine make it an essential molecule in cellular processes and a potential target for drug development.

Upstream product

• 634-02-6 guanosine 2',3'-cyclic monophosphate 
• 58-96-8 uridine 

Downstream Products

• 117-68-0 guanosine 3'-monophosphate 
• 58-96-8 uridine 
• 634-02-6 guanosine 2',3'-cyclic monophosphate 

Relevant articles and documents

Chemical synthesis of RNA via 2′-O-cyanoethylated intermediates

It was found that 2′-O-cyanoethyl group could be removed from 2′-O-cyanoethylated ribonucleoside derivatives by treatment with Bu4NF. This finding was successfully applied to the synthesis of oligoribonucleotides via their 2′-O-cyanoethylated derivatives as key intermediates where a cyanoethyl group was used as the 2′-hydroxyl protecting group. The rate of condensation using this protecting group in the presence of various activators was generally faster than that observed when a TBDMS group was used as the protecting group.

Synthetic reactions of ribonuclease T1.

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