479-30-1

Basic information

• Product Name: 3,4-Pyridinedicarboxylic acid, 5-hydroxy-6-methyl-
• Synonyms: 3,4-Pyridinedicarboxylic acid, 5-hydroxy-6-methyl-;3-Hydroxy-2-methyl-4,5-pyridinedicarboxylic acid;3-Hydroxy-2-methylpyridine-4,5-dicarboxylic acid;6-Methyl-5-hydroxypyridine-3,4-dicarboxylic acid;Ichiba acid;LVJJEIJOKPHQOU-UHFFFAOYSA-N
• CAS NO: 479-30-1
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• Mol File: 479-30-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-Pyridinedicarboxylic acid, 5-hydroxy-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Pyridinedicarboxylic acid, 5-hydroxy-6-methyl-(479-30-1)
• EPA Substance Registry System: 3,4-Pyridinedicarboxylic acid, 5-hydroxy-6-methyl-(479-30-1)

Safety Data

• Hazardous Substances Data: 479-30-1(Hazardous Substances Data)

Usage

Uses

5-Hydroxy-6-methyl-3,4-pyridinedicarboxylic Acid is used in studies to identify 4-pyridoxic acid dehydrogenase gene in pyridoxine catabolism of Mesorhizobium loti MAFF303099.

Upstream product

• 5442-82-0 3-amino-2-methylpyridin-4,5-dicarboxylic acid 
• 18872-74-7 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 2397-71-9 5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester 
• 18724-73-7 methyl 3-cyano-2-hydroxy-6-methyl-isonicotinate 
• 18619-97-1 ethyl 3-cyano-2-hydroxy-6-methylisonicotinate 
• 90840-50-9 ethyl 2-methyl-3-amino-5-cyanopyridine-4-carboxylate 
• 109069-83-2 3-amino-6-chloro-5-cyano-2-methyl-isonicotinic acid methyl ester 
• 99421-19-9 ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate 
• 90110-24-0 3-amino-6-chloro-2-methylpyridin-4,5-dicarboxylic acid 
• 82-82-6 4-pyridoxic acid 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 860426-55-7 {[benzyl-(1-methoxycarbonyl-ethyl)-amino]-methylene}-succinic acid dimethyl ester 
• 5427-92-9 3-cyano-2-hydroxy-6-methyl-5-nitro-isonicotinic acid ethyl ester 
• 72701-63-4 2-chloro-3-cyano-6-methyl-5-nitro-isonicotinic acid ethyl ester 

Downstream Products

• 103269-62-1 5-benzyloxy-6-methyl-pyridine-3,4-dicarboxylic acid dibenzyl ester 
• 65-23-6 5-hydroxy-6-methyl-3,4-pyridinedimethanol 
• 18872-74-7 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 7442-21-9 [5-(benzyloxy)-4-(hydroxymethyl)-6-methylpyridin-3-yl]methanol 
• 633-72-7 4,5-bis-hydroxymethyl-3-methoxy-2-methyl-pyridine 

Relevant articles and documents

PLP catabolism: Identification of the 4-pyridoxic acid dehydrogenase gene in Mesorhizobium loti MAFF303099

The function of the mlr6793 gene from Mesorhizobium loti MAFF303099 has been identified. This gene encodes 4-pyridoxic acid dehydrogenase, an enzyme involved in the catabolism of PLP (Vitamin B6). This enzyme was overexpressed in Escherichia coli and characterized. 4-Pyridoxic acid dehydrogenase is a 33 kDa protein that catalyzes the four electron oxidation of 4-pyridoxic acid to 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, using nicotinamide adenine dinucleotide as a cofactor. The kcat for NADH production is 0.01 s-1. The KM values for 4-pyridoxic acid and NAD are 5.8 and 6.6 μM, respectively.