48068-25-3

Basic information

• Product Name: BOC-THR(ME)-OH
• Synonyms: BOC-THR(ME)-OH;BOC-O-METHYL-L-THREONINE;N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-THREONINE;(2S,3R)-2-(tert-butoxycarbonylamino)-3-methoxybutanoic acid;O-Methyl-L-threonine, N-BOC protected;N-Boc-O-Methyl-L-threonine;Boc-L-Thr(Me)-OH;(Tert-Butoxy)Carbonyl Thr(Me)-OH
• CAS NO: 48068-25-3
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.26
• Mol File: 48068-25-3.mol

Chemical Properties

• Boiling Point: 362.1±37.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.123±0.06 g/cm3(Predicted)
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: BOC-THR(ME)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-THR(ME)-OH(48068-25-3)
• EPA Substance Registry System: BOC-THR(ME)-OH(48068-25-3)

Safety Data

• Hazardous Substances Data: 48068-25-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Biotechnology Production:
BOC-THR(ME)-OH is used as a building block in peptide synthesis for creating peptides with specific sequences and structures. Its role in the development of pharmaceutical and biotechnology products is significant due to its ability to contribute to the formation of complex and functional peptide chains.
Used in Organic Synthesis:
BOC-THR(ME)-OH serves as a chiral auxiliary in organic synthesis, aiding in the creation of enantiomerically pure compounds. This application is vital for the production of pharmaceuticals and other chemicals where stereochemistry is critical for biological activity and selectivity.
Used as a Precursor for Threonine Derivatives:
BOC-THR(ME)-OH is utilized as a precursor for the preparation of various threonine derivatives. These derivatives can have diverse applications in different fields, including medicine, agriculture, and materials science, depending on their specific properties and functions.

InChI:InChI=1/C10H19NO5/c1-6(15-5)7(8(12)13)11-9(14)16-10(2,3)4/h6-7H,1-5H3,(H,11,14)(H,12,13)/t6?,7-/m0/s1

Upstream product

• 4144-02-9 O-methyl-L-threonine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2592-18-9 Boc-Thr-OH 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 74-88-4 methyl iodide 

Downstream Products

• 102979-58-8 Boc-Thr(OCH₃)-Phe-Phe-Gly-OBzl 
• 1449473-70-4 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-1H-benzimidazol-5-yl}-3-chlorobenzonitrile formate 
• 1449473-81-7 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate 
• 1301706-86-4 N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-methyl-L-threonine 
• 4144-02-9 O-methyl-L-threonine 
• 537697-19-1 tert-butyl ((2R,3R)-1-hydroxy-3-methoxybutan-2-yl)carbamate 
• 1449476-01-0 tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate 
• 1422128-54-8 N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N,O-trimethyl-L-threoninamide 

Relevant articles and documents

BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS

The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.

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