481-96-9

Basic information

• Product Name: estradiol-3-sulfate
• Synonyms: estradiol-3-sulfate;17beta-estradiol 3-sulfate
• CAS NO: 481-96-9
• Molecular Formula: C₁₈H₂₄O₅S
• Molecular Weight: 352.45
• Mol File: 481-96-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.354g/cm³
• Refractive Index: 1.605
• CAS DataBase Reference: estradiol-3-sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: estradiol-3-sulfate(481-96-9)
• EPA Substance Registry System: estradiol-3-sulfate(481-96-9)

Safety Data

• Hazardous Substances Data: 481-96-9(Hazardous Substances Data)

Usage

Definition

ChEBI: A steroid sulfate obtained by the formal consensation of sulfuric acid with the hydroxy group of 17beta-estradiol.

InChI:InChI=1/C18H24O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,17+,18+/m1/s1

Upstream product

• 50-28-2 estradiol 

Relevant articles and documents

Sulfation made easy: A new versatile donor for enzymatic sulfation by a bacterial arylsulfotransferase

An efficient and versatile donor for the sulfation by a bacterial arylsulfotransferase of various phenolic acceptor molecules is reported. Most studies in the past used toxic p-nitrophenyl sulfate as a sulfate donor for sulfation by this enzyme. However both the donor and p-nitrophenol are difficult to remove from the sulfated products. This new donor N-hydroxysuccinimide sulfate is easy to synthesize and has the advantage that at pH values above 7 it hydrolyzes to N-hydroxysuccinimide which is a safe compound and can easily be removed. As examples we demonstrated the formation of sulfated resveratrol and synthesized efficiently 3-sulfo-17-β-estradiol and bisphenol A bisulfate. It is likely that many other phenolic compounds are sulfated using this donor.