482-45-1

Basic information

• Product Name: Isoimperatorin
• Synonyms: ISOIMPERATORIN;4-PRENYLOXYPSORALEN;4-(3-Methyl-but-2-enyloxy-furo[3,2-g]chromen-7-one;ISOIMPERATORIN(P);Isomperatorin;4-(3-Methylbut-2-enoxy)furo[3,2-g]chromen-7-one;4-(3-Methyl-but-2-enyloxy-furo[3,2-γ],chromen-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-
• CAS NO: 482-45-1
• Molecular Formula: C16H14O4
• Molecular Weight: 270.28
• EINECS: 1308068-626-2
• Product Categories: Miscellaneous Natural Products;Heterocyclic Compounds;Heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 482-45-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 107-111°C
• Boiling Point: 448.3 °C at 760 mmHg
• Flash Point: 224.9 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 3.13E-08mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly
• BRN: 1291723
• CAS DataBase Reference: Isoimperatorin(CAS DataBase Reference)
• NIST Chemistry Reference: Isoimperatorin(482-45-1)
• EPA Substance Registry System: Isoimperatorin(482-45-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: LV1513000
• Hazardous Substances Data: 482-45-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 482-45-1 differently. You can refer to the following data:
1. Anti-inflammatory. Effect on proliferation
2. Anti-inflammatory. Effect on proliferation.

Definition

ChEBI: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.

InChI:InChI=1/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3

Upstream product

• 486-60-2 bergaptol 
• 870-63-3 prenyl bromide 
• 358-72-5 dimethylallyl diphosphate 
• 484-20-8 bergapten 

Downstream Products

• 486-60-2 bergaptol 
• 2643-85-8 oxypeucedanin hydrate 
• 737-52-0 oxypeucedanin 

Relevant articles and documents

Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants

Plants produce ～300 aromatic compounds enzymatically linked to prenyl side chains via C–O bonds. These O-prenylated aromatic compounds have been found in taxonomically distant plant taxa, with some of them being beneficial or detrimental to human health. Although their O-prenyl moieties often play crucial roles in the biological activities of these compounds, no plant gene encoding an aromatic O-prenyltransferase (O-PT) has been isolated to date. This study describes the isolation of an aromatic O-PT gene, CpPT1, belonging to the UbiA superfamily, from grapefruit (Citrus × paradisi, Rutaceae). This gene was shown responsible for the biosynthesis of O-prenylated coumarin derivatives that alter drug pharmacokinetics in the human body. Another coumarin O-PT gene encoding a protein of the same family was identified in Angelica keiskei, an apiaceous medicinal plant containing pharmaceutically active O-prenylated coumarins. Phylogenetic analysis of these O-PTs suggested that aromatic O-prenylation activity evolved independently from the same ancestral gene in these distant plant taxa. These findings shed light on understanding the evolution of plant secondary (specialized) metabolites via the UbiA superfamily.

Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4

A number of furanocoumarins isolated from grapefruit juice have been found to inhibit CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of analogues based on bergamottin to investigate the relationship between chemical stru