483324-01-2

Basic information

• Product Name: 4-(3-Pyridyl)-2-chloropyrimidine
• Synonyms: 2-Chloro-4-pyridin-3-yl-pyrimidine;2-Chloro-4-(3-pyridyl)pyrimidine;4-(3-Pyridyl)-2-chloropyrimidine;PyriMidine, 2-chloro-4-(3-pyridinyl)-;4-(3-pyridyl)-2-chloropyrimidine:2-chloro-4-(3-pyridyl)pyrimidine:
• CAS NO: 483324-01-2
• Molecular Formula: C₉H₆ClN₃
• Molecular Weight: 191.62
• Product Categories: Heterocyclic Building Blocks
• Mol File: 483324-01-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 399.5 °C at 760 mmHg
• Flash Point: 227.7 °C
• Appearance: /
• Density: 1.309
• Vapor Pressure: 3.14E-06mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.34±0.12(Predicted)
• CAS DataBase Reference: 4-(3-Pyridyl)-2-chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Pyridyl)-2-chloropyrimidine(483324-01-2)
• EPA Substance Registry System: 4-(3-Pyridyl)-2-chloropyrimidine(483324-01-2)

Safety Data

• Hazardous Substances Data: 483324-01-2(Hazardous Substances Data)

Usage

General Description

4-(3-Pyridyl)-2-chloropyrimidine, also known as 2-Chloro-4-(3-pyridyl)pyrimidine, is a chemical compound with the molecular formula C8H6ClN3. It is a pyrimidine derivative that contains a chloro group and a pyridyl group as its functional groups. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also employed in the development of biologically active compounds, including potential anticancer and antimicrobial agents. Additionally, 4-(3-Pyridyl)-2-chloropyrimidine may be utilized in various research applications in the fields of medicinal and organic chemistry.

InChI:InChI=1/C9H6ClN3/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H

Upstream product

• 626-55-1 3-Bromopyridine 
• 1722-12-9 2-chloropyrimidine 
• 220565-63-9 pyridin-3-ylzinc(II) bromide 
• 3934-20-1 2,6-Dichloropyrimidine 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 60573-68-4 3-pyridyllithium 
• 897031-20-8 4-(pyridin-3-yl)-1,2-dihydropyrimidin-2-one 
• 1692-25-7 3-pyridylboronic acid 

Downstream Products

• 112675-67-9 N-(4-methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 
• 611225-84-4 2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine 
• 641569-97-3 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester 
• 152460-10-1 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 917392-54-2 methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate 
• 641571-10-0 nilotinib 
• 152459-95-5 imatinib 
• 641569-94-0 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid 
• 1352242-48-8 2-methyl-N₁-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 796738-71-1 N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 
• 66521-66-2 4-pyridin-3-ylpyrimidin-2-ylamine 

Relevant articles and documents

SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE

Processes and useful intermediates for the synthesis of the tyrosine kinase inhibitors Formula (II) nilotinib and Formula (IV) imatinib. Key intermediates, method for their synthesis and their use in a divergent synthesis, making use of a Curtius rearrangement, to nilotinib and imatinib are described.

N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity, and preparation method thereof

The invention discloses an N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity, and a preparation method thereof, and belongs to the technical field of medicine synthesis. The structural formula of the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity is shown in the description. The invention also discloses a preparation method for the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with anti-cancer activity. The N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative prepared with the preparation method has good inhibition activity for lung carcinoma cells A549, and has a potential for becoming an anti-tumor medicine.

Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors

A series of novel hedgehog signaling pathway inhibitors have been designed and synthesized based on our previously reported scaffold of 4-(2-pyrimidinylamino)benzamide. The Hh signaling pathway inhibitory activities were evaluated by Gli-luciferase reporter method and most compounds showed more potent inhibitory activities than vismodegib. Three compounds were picked out to evaluated in vivo for their PK properties, and compound 23b bearing a 2-pyridyl A-ring and (morpholin-4-yl)methylene at 3-position of D-ring demonstrated satisfactory PK properties. This study suggested the 4-(2-pyrimidinylamino)benzamides were a series of potent Hh signaling pathway inhibitors, deserving to further structural optimization.