4852-22-6

Basic information

• Product Name: Procyanidin
• Synonyms: Moringa oleifera seed extract;Procyanidin (water soluble);PROCYANIDINE;2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl)oxy)-3,4-dihydro-2H-1-benzopyran-3,4,5,7-tetrol;Procyanidin;2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroMan-3-yl)oxy)chroMan-3,4,5,7-tetraol;OligoMericProanthoCyanidins(OPC)
• CAS NO: 4852-22-6
• Molecular Formula: C₃₀H₂₆O₁₃
• Molecular Weight: 594.52
• EINECS: 1806241-263-5
• Product Categories: pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;chemical reagent
• Mol File: 4852-22-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 986.4 °C at 760 mmHg
• Flash Point: 550.3 °C
• Appearance: /
• Density: 1.87 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.876
• CAS DataBase Reference: Procyanidin(CAS DataBase Reference)
• NIST Chemistry Reference: Procyanidin(4852-22-6)
• EPA Substance Registry System: Procyanidin(4852-22-6)

Safety Data

• Hazardous Substances Data: 4852-22-6(Hazardous Substances Data)

Usage

Chemical properties

Oligomeric procyanidin is easily soluble in polar solvents such as water, alcohol, ketone, glacial acetic acid and ethyl acetate, but insoluble in weak polar solvents such as petroleum ether, chloroform and benzene. Polymeric procyanidin is insoluble in hot water but soluble in alcohol or sulfite solution.

Uses

Procyanidin is a new type of high-efficiency antioxidant and the most powerful free radical scavenger discovered so far. It has very strong in vivo activity and is used to improve blood circulation, treat diabetic retinopathy, reduce edema and inhibit varicose veins, etc.

Pharmacology

Procyanidin can be rapidly absorbed in the gastrointestinal tract, reaching a peak value in 45min, with a half-life of 5h, 14% is excreted in bile within 11h, and 70% is excreted in the form of CO2, urine and feces after 24h, and is non-specifically bound in blood, liver and kidney. It binds specifically to the skin, blood vessel wall, and gastrointestinal mucosa, and is characterized by elevated levels of glucaminoglycans. Its main target organ is connective tissue, and its metabolism has an important entero-hepatic circulation.

Chemical Synthesis

At present, the commonly used process to synthesis?Procyanidin is to degreasing first, including squeezing method, solvent method, and supercritical CO2 extraction method. Among them, supercritical CO2 extraction method is the best, not only has high oil extraction rate, but also has the least destructive effect on proanthocyanidins, and the quality is relatively high.

InChI:InChI=1/C30H26O13/c31-14-7-19(35)16-11-25(28(41-23(16)9-14)12-1-3-17(33)20(36)5-12)43-30(13-2-4-18(34)21(37)6-13)29(40)27(39)26-22(38)8-15(32)10-24(26)42-30/h1-10,25,27-29,31-40H,11H2

Relevant articles and documents

Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof

Proanthocyanidin-containing compositions with excellent proanthocyanidin stability, as well as drinks, foods, cosmetics and medicaments containing these compositions, are provided by admixing a vitamin B6derivative or its salt in proanthocyanidin. Also shown is a method for stabilizing proanthocyanidin to prevent its color change, etc. caused by oxidative polymerization and the like.