488713-52-6

Basic information

• Product Name: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid
• Synonyms: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid
• CAS NO: 488713-52-6
• Molecular Weight: 485.456
• Mol File: 488713-52-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid(488713-52-6)
• EPA Substance Registry System: 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid(488713-52-6)

Safety Data

• Hazardous Substances Data: 488713-52-6(Hazardous Substances Data)

Upstream product

• 488713-20-8 2-(3-formyl-4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 488713-18-4 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 878674-38-5 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-2'-hydroxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester 
• 22248-26-6 2-(4-methoxy-phenyl)-succinic acid dimethyl ester 
• 136705-25-4 (4-hydroxy-phenyl)-succinic acid dimethyl ester 
• 23053-35-2 2-(4'-hydroxyphenyl)butane-1,4-dioic acid 
• 696-62-8 para-iodoanisole 
• 883993-75-7 2-[5'-cyano-5-formyl-6,2'-bis-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester 
• 488713-67-3 2-[3-formyl-4-(2-methoxy-ethoxymethoxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-phenyl]-succinic acid dimethyl ester 
• 878673-54-2 2-[3-bromo-5-formyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester 

Downstream Products

• 488713-71-9 2-[5'-aminomethyl-5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-biphenyl-3-yl]-succinic acid 
• 488713-96-8 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-hydroxymethyl-biphenyl-3-yl]-succinic acid 

Relevant articles and documents

Factor VIIa inhibitors: Gaining selectivity within the trypsin family

Within the trypsin family of coagulation proteases, obtaining highly selective inhibitors of factor VIIa has been challenging. We report a series of factor VIIa (fVIIa) inhibitors based on the 5-amidino-2-(2-hydroxy-biphenyl-3- yl)-benzimidazole (1) scaff

2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.