488831-39-6

Basic information

• Product Name: [3-(4'-chloro-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-methanol
• CAS NO: 488831-39-6
• Molecular Weight: 298.772
• Mol File: 488831-39-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3-(4'-chloro-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(4'-chloro-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-methanol(488831-39-6)
• EPA Substance Registry System: [3-(4'-chloro-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-methanol(488831-39-6)

Safety Data

• Hazardous Substances Data: 488831-39-6(Hazardous Substances Data)

Upstream product

• 26177-44-6 4-bromobenzylamine hydrochloride 
• 1679-18-1 4-Chlorophenylboronic acid 
• 220364-22-7 1-(4-Bromobenzyl)-5-hydroxymethyl-1H-imidazole 

Downstream Products

• 238764-78-8 3-(4'-chloro-biphenyl-4-ylmethyl)-3H-imidazole-4-carbaldehyde 

Relevant articles and documents

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Compound 1 has been shown to be a dual prenylation inhibitor with FPTase (IC50=2 nM) and GGPTase-I (IC50=95 nM). Analogues of 1, which replaced the cyanophenyl group with various biaryls, led to the discovery of highly potent dual FPTase/GGPTase-I inhibitors. 4-Trifluoromethylphenyl, trifluoropentynyl, and trifluoropentyl were identified as good p-cyano replacements.