490030-16-5Relevant articles and documents
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors
Koda, Yasuko,Kikuzato, Ko,Mikuni, Junko,Tanaka, Akiko,Yuki, Hitomi,Honma, Teruki,Tomabechi, Yuri,Kukimoto-Niino, Mutsuko,Shirouzu, Mikako,Shirai, Fumiyuki,Koyama, Hiroo
, p. 4994 - 4998 (2017)
A series of novel pyrrolo[2,3-d]pyrimidines were synthesized by introducing 15 different amino acids to 7-cyclohexyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine. Compounds with potent activities against HCK and FLT3-ITD were evaluated in viabi
AGENT FOR TREATING OR CONTROLLING RECURRENCE OF ACUTE MYELOGENOUS LEUKEMIA
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Paragraph 0155, (2015/06/16)
This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Ar1 and Ar