4920-79-0

Basic information

• Product Name: 2-Chloro-4-nitoranisole
• Synonyms: 3-CHLORO-4-METHOXYNITROBENZENE;2-chloro-4-nitoranisole;2-CHLORO-4-NITROANISOLE;2-CHLORO-1-METHOXY-4-NITROBENZENE;2-chloro-1-methoxy-4-nitro-benzen;2-chloro-4-nitro-anisol;Anisole, 2-chloro-4-nitro-;Chloronitroanisole
• CAS NO: 4920-79-0
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• EINECS: 225-547-4
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Nitro Compounds
• Mol File: 4920-79-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 286.598 °C at 760 mmHg
• Flash Point: 127.13 °C
• Appearance: /
• Density: 1.367 g/cm³
• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4-nitoranisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-nitoranisole(4920-79-0)
• EPA Substance Registry System: 2-Chloro-4-nitoranisole(4920-79-0)

Safety Data

• Hazard Codes: Xi
• RTECS: BZ8578000
• HazardClass: IRRITANT
• Hazardous Substances Data: 4920-79-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-nitroanisole is a synthetic, organic compound that falls under the category of aromatic ethers. Its molecular formula is C7H6ClNO3 and it possesses a molecular weight of 187.580 g/mol. 2-Chloro-4-nitoranisole is a pale-yellow crystalline solid and it features a nitro group (-NO2) and a methoxy group (-OCH3) as functional groups. It is primarily used in the synthesis of other complex organic compounds, often serving as a precursor or an intermediate. As a nitroaromatic compound, it's highly likely to be toxic and potentially explosive, therefore, it requires careful handling. The exact toxicological properties, potential risk factors, or safety handling instructions are not fully known and may differ based on its application and context of use.

InChI:InChI=1/C7H6ClNO3/c1-12-7-3-2-5(9(10)11)4-6(7)8/h2-4H,1H3

Upstream product

• 871896-67-2 4-chloro-5-methoxy-benzo[1,2,5]oxadiazole 1-oxide 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 619-08-9 2-chloro-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 766-51-8 2-Chloroanisole 
• 108-24-7 acetic anhydride 
• 619-16-9 1-chloro-2,5-dinitrobenzene 
• 124-41-4 sodium methylate 
• 99-54-7 3,4-dichloronitrobenzene 
• 67-56-1 methanol 
• 7697-37-2 nitric acid 
• 100-17-4 para-methoxynitrobenzene 
• 89975-38-2 2-chloro-3-methoxy-6-nitroaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 69753-56-6 N-(3-chloro-4-methoxyphenyl)formamide 
• 68935-48-8 4-chloro-5-methoxy-1H-indole 
• 90234-41-6 3-chloro-4-methoxy-N-methylaniline 
• 1007122-94-2 C₈H₆ClN₂O₃^(1-) 
• 10496-75-0 2-methoxy-5-nitrobenzylnitrile 
• 102151-33-7 3-Chloro-4-methoxybenzonitrile 
• 18093-12-4 3-chloro-4-methoxyphenol 
• 619-08-9 2-chloro-4-nitrophenol 
• 636-93-1 5-nitroguaiacol 
• 118702-10-6 S-(-)-β-methyl-6-chloromelatonin 
• 619-10-3 5-nitro-2-chlorophenol 
• 858244-81-2 formic acid-(3-chloro-4-methoxy-N-methyl-anilide) 
• 23165-42-6 3-chloro-4-methoxyphenyl isothiocyanate 

Relevant articles and documents

-

-

4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents

Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4′-methoxy)anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8- nitroquinazolines were designed and synthesized to investigate the effect of the substitution on the inhibitory activity against mitotic progression of tumor cells. The large alkoxyl substitution on the 4′-position of 5-anilino ring is beneficial for the potency. The 5-(3′,4′,5′-trimethoxy)anilino-8-nitroquinazoline (1h) displays an overwhelming activity in arresting the cells at the G2/M phase, providing a promising new template for further development of potent microtubule-targeted anti-mitotic drugs.

Oxidative chlorination of various lodoarenes to (dichloroiodo)arenes with chromium(vi) oxide as the oxidant j

Chromium(vi) oxide dissolved in a mixture of acetic acid with concentrated hydrochloric acid converts, at or near room temperature, iodoarenes to (dichloroiodo)arenes, in a very simple and efficient procedure.