492431-11-5

Basic information

• Product Name: 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 1-Boc-4-(6-chloropyridazin-3-yl)piperazine;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid t-Butyl Ester;Zinc02563759;1-N-Boc-4-(6-chloropyridazin-3-yl)piperazine;tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate;1-Boc-4-(6-chloro-3-pyridazinyl)piperazine;1-Boc-4-(6-Chloropyridazin-3-yl);4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS NO: 492431-11-5
• Molecular Formula: C₁₃H₁₉ClN₄O₂
• Molecular Weight: 298.77
• Mol File: 492431-11-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 472.5 °C at 760 mmHg
• Flash Point: 239.5 °C
• Appearance: /
• Density: 1.253 g/cm³
• Vapor Pressure: 4.27E-09mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(492431-11-5)
• EPA Substance Registry System: 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(492431-11-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 492431-11-5(Hazardous Substances Data)

Usage

Uses

4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid tert-Butyl Ester

InChI:InChI=1/C13H19ClN4O2/c1-13(2,3)20-12(19)18-8-6-17(7-9-18)11-5-4-10(14)15-16-11/h4-5H,6-9H2,1-3H3

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 145276-53-5 6-(piperazin-1-yl)pyridazin-3(2H)-one 
• 1379522-31-2 tert-butyl 4-(6-{[4-(methylsulfonyl)benzyl]oxy}pyridazin-3-yl)piperazine-1-carboxylate 
• 1256963-23-1 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 56392-83-7 3-chloro-6-piperazin-1-yl-pyridazine 
• 492431-12-6 tert-butyl 4-(pyridazin-3-yl)piperazine-1-carboxylate 

Relevant articles and documents

CRYSTAL OF PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE OR SOLVATE THEREOF

Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE

Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.